1001名HIV感染者鼻腔MRCoNS与MSCoNS耐药谱比较  

Comparison of antibiotic resistance spectrum between methicillin-resistant and methicillin-susceptible coagulase-negative staphylococci nasal isolates among 1 001 HIV infectors

作　　者：何穗平 叶家萍 白婵 李凌华[2] 李丽雅[2] 蔡卫平[2] 王莹莹 李荧 张文萃 刘宁 贡梓军 姚振江 HE Sui-ping;YE Jia-ping;BAI Chan;LI Ling-hua;LI Li-ya;CAI Wei-ping;WANG Ying-ying;LI Ying;ZHANG Wencui;LIU Ning;GONG Zi-jun;YAO Zhen-jiang(Department of Epidemiology and Biostatistics,School of Public Health,Guangdong Pharmaceutical University,Guangzhou 510310,China;Department of Infectious Diseases,Guangzhou No.8 Peoples Hospital,Guangzhou 510060,Chinn)

机构地区：[1]广东药科大学公共卫生学院流行病与卫生统计学系,广州510310 [2]广州市第八人民医院感染科,广州510060

出　　处：《中华疾病控制杂志》2019年第12期1527-1530,共4页Chinese Journal of Disease Control & Prevention

基　　金：广东省科技计划项目(2014A020213013)~~

摘　　要：目的探究广州市人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者鼻腔凝固酶阴性葡萄球菌(coagulase-negative staphylococci,CoNS)携带情况和耐药谱特征。方法对广州市某医院艾滋病门诊部HIV感染者鼻腔分离出的CoNS进行药敏试验和耐药基因检测。结果 1 001名HIV感染者鼻腔CoNS和耐甲氧西林凝固酶阴性葡萄球菌(methicillin-resistant coagulase-negative staphylococci,MRCoNS)携带率分别为57.44%和48.15%,MRCoNS对青霉素、红霉素和复方新诺明耐药率较高,主要携带Aac(6’)-aph(2’)、ermC和linA耐药基因。MRCoNS(80.69%)与甲氧西林敏感凝固酶阴性葡萄球菌(methicillin-susceptible coagulase-negative staphylococci,MSCoNS)(39.66%)多重耐药率差异有统计学意义(χ~2=100.27,P<0.001)。结论广州市HIV感染者鼻腔CoNS和MRCoNS携带率及多重耐药率均较高,与MSCoNS相比MRCoNS可增加6.36倍多重耐药风险。Objective We aimed to elucidate the prevalence and the antibiotic resistance spectrum of nasal coagulase-negative staphylococci(CoNS) colonization among HIV infectors in Guangzhou. Method After isolation and identification, all CoNS isolates were tested for the antibiotic susceptibility, and the antibiotic resistance genes. Result Among the 1 001 HIV infectors, the prevalence of CoNS and MRCoNS were 57.44% and 48.15%, respectively. The three predominant resistant antibiotics of MRCoNS isolates were penicillin, erythromycin and trimethoprim-sulfame thoxazole, while predominant detection rates of genes were Aac(6’)-aph(2’)、ermC and linA genes. The multidrug resistance rate of MRCoNS isolates were significantly higher than methicillin-susceptible coagulase-negative staphylococci(MSCoNS) isolates(80.69% versus 39.66%, P<0.001, OR=6.36). Conclusions The prevalence and multidrug resistant rates of nasal colonization CoNS and MRCoNS are high among HIV infectors in Guangzhou. MRCoNS isolates were 6.36 times more likely to be of multidrug resistance than MSCoNS isolates.

关 键 词：HIV感染者 凝固酶阴性葡萄球菌 耐甲氧西林凝固酶阴性葡萄球菌 耐药谱 

分 类 号：R378.1[医药卫生—病原生物学]