清脑复神液联合尼莫地平治疗血管性认知障碍的临床研究  

Clinical study on Qingnao Fushen Liquid combined with nimodipine in treatment of vascular cognitive impairment

作　　者：何林[1] 钟琪[2] 陈劲松[1] HE Lin;ZHONG Qi;CHEN Jin-song(Department of Rehabilitation,Mianyang Central Hospital,Mianyang 621000,China;Department of Neurosurgery,Mianyang Central Hospital,Mianyang 621000,China)

机构地区：[1]绵阳市中心医院康复科,四川绵阳621000 [2]绵阳市中心医院神经外科,四川绵阳621000

出　　处：《现代药物与临床》2019年第11期3236-3239,共4页Drugs & Clinic

摘　　要：目的研究清脑复神液联合尼莫地平片治疗血管性认知障碍的临床疗效。方法选取2015年12月-2018年12月绵阳市中心医院收治的115例血管性认知障碍患者为研究对象,将所有患者随机分为对照组(57例)和治疗组(58例)。对照组患者口服尼莫地平,2片/次,4次/d;治疗组在对照组基础上口服清脑复神液,10 mL/次,2次/d。两组患者持续治疗8周。观察两组的临床疗效,比较两组的蒙特利尔认知评估量表(MoCA)评分、简易精神智能量表(MMSE)评分、血清因子水平。结果治疗后,对照组和治疗组的总有效率分别为85.96%、93.10%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者MoCA评分和MMSE评分均显著升高,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组患者MoCA评分和MMSE评分明显高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者神经元特异性烯醇化酶(NSE)和血栓素B2(TXB2)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组患者血清因子水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论清脑复神液联合尼莫地平片治疗血管性认知障碍具有较好的治疗效果,能改善患者认知功能,降低NSE和TXB2水平,具有一定的临床推广应用价值。Objective To investigate the effect of Qingnao Fushen Liquid combined with Nimodipine Tablets in treatment of vascular cognitive impairment. Methods Patients(115 cases) with vascular cognitive impairment in Mianyang Central Hospital from December 2015 to December 2018 were randomly divided into the control group(57 cases) and the treatment group(58 cases). Patients in the control group were po administered with Nimodipine Tablets, 2 tablets/time, twice daily. Patients in the treatment group were poadministered with Qingnao Fushen Liquid on the basis of the control group, 10 mL/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and MoCA score, MMSE score, and serum factors levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.96% and 93.10%, and there was difference between two groups(P < 0.05). After treatment, MoCA score and MMSE score in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the scores in the treatment group were significantly higher than those in the control group(P < 0.05). After treatment, the levels of NSE and TXB2 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the serum factors levels in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Qingnao Fushen Liquid combined with Nimodipine Tablets has clinical curative effect in treatment of vascular cognitive impairment, can improve the cognitive function of patients, reduce the levels of NSE and TXB2, which has a certain clinical application value.

关 键 词：清脑复神液 尼莫地平片 血管性认知障碍 MoCA评分 MMSE评分 血清因子 

分 类 号：R971[医药卫生—药品]