炎琥宁注射液联合依替米星治疗老年社区获得性肺炎的临床研究  

Clinical study on Yanhuning Injection combined with etimicin in treatment of community-acquired pneumonia in the elderly

作　　者：周玉涛[1] 臧菊香 庄红娟[3] ZHOU Yu-tao;ZANG Ju-xiang;ZHUANG Hong-juan(Department of Respiratory Medicine,Liyang People's Hospital,Changzhou 213300,China;Department of Pharmacy,General Hospital of Eastern War Zone,Nanjing 210002,China;Department of Pharmacy,Liyang People's Hospital,Changzhou 213300,China)

机构地区：[1]溧阳市人民医院呼吸内科,江苏常州213300 [2]东部战区总医院药学科,江苏南京210002 [3]溧阳市人民医院药学科,江苏常州213300

出　　处：《现代药物与临床》2019年第11期3271-3274,共4页Drugs & Clinic

摘　　要：目的探讨炎琥宁注射液联合依替米星治疗老年社区获得性肺炎的临床疗效。方法选择2018年4月-2019年4月在溧阳市人民医院治疗的社区获得性肺炎老年患者86例,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组静脉滴注硫酸依替米星注射液,0.2g加入生理盐水250m L,1次/d;治疗组在对照组的基础上静脉滴注炎琥宁注射液,0.4 g/次,1次/d。两组患者均经7 d治疗。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状改善时间、CURB-65评分、LCQ评分及血清C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-17(IL-17)、半乳糖凝集素3(GAL3)和肿瘤坏死因子-α(TNF-α)水平。结果治疗后,对照组和治疗组临床有效率分别为81.40%和97.67%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组患者的咳嗽、胸痛、发热和肺部啰音消失时间均明显早于对照组(P<0.05)。治疗后,两组患者LCQ评分明显升高(P<0.05),CURB-65评分明显下降(P<0.05),且治疗组CURB-65和LCQ评分明显好于对照组(P<0.05)。治疗后,两组患者血清CRP、PCT、IL-17、Gal-3、TNF-α水平均显著降低(P<0.05),且治疗组CRP、PCT、IL-17、Gal-3、TNF-α水平明显低于对照组(P<0.05)。结论炎琥宁注射液联合依替米星治疗老年社区获得性肺炎可有效改善患者临床症状,降低机体炎症反应。Objective To investigate the clinical efficacy of Yanhuning Injection combined with etimicin in treatment of communityacquired pneumonia in the elderly. Methods Patients(86 cases) with community-acquired pneumonia in Liyang People’s Hospital from April 2018 to April 2019 were divided into control(43 cases) and treatment(43 cases) groups based on different treatments. Patients in the control group were iv administered with Etimicin Sulfate Injection, 0.2 g/time added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Yanhuning Injection on the basis of the control group, 0.4 g/time, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the symptoms improvement time, CURB-65 scores, LCQ scores, and serum levels of CRP, PCT, IL-17, GAL3, and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.40% and 97.67%, respectively, and there were differences between two groups(P < 0.05). After treatment, the disappearing time of cough, chest pain, fever, and lung rales in the treatment group were significant earlier than those in the control group(P < 0.05). After treatment, the LCQ scores in two groups were significantly increased(P < 0.05), but CURB-65 scores were significantly decreased(P < 0.05), and the CURB-65 and LCQ scores in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the serum levels of CRP, PCT, IL-17, GAL3, and TNF-α in two groups were significantly decreased(P < 0.05), and these serum indexes in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Yanhuning Injection combined with etimicin in treatment of community-acquired pneumonia in the elderly can effectively improve the clinical symptoms, reduce the inflammatory response.

关 键 词：炎琥宁注射液 硫酸依替米星注射液 社区获得性肺炎 C反应蛋白 降钙素原 半乳糖凝集素3 

分 类 号：R974[医药卫生—药品]