母孕期和婴儿早期膳食钙剂补充对婴儿肠道菌群的影响  

Effect of calcium supplementation on neonatal intestinal flora during pregnancy and early pregnancy

作　　者：黄荣平 庄辉耀 姜秋泉 占雪梅 HUANG Rongping;ZHUANG Huiyao;JIANG Qiuquan;ZHAN Xuemei(Department of Pharmacy,Xixi Hospital,Hangzhou 310023,Zhejiang,China;Department of Pediatrics,Xixi Hospital,Hangzhou 310023,Zhejiang,China)

机构地区：[1]杭州市西溪医院药剂科,浙江杭州310023 [2]杭州市西溪医院儿科,浙江杭州310023

出　　处：《中国妇幼健康研究》2019年第11期1394-1399,共6页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨母孕期和婴儿早期补充钙剂对新生儿肠道菌群的影响。方法选取2017年3至9月在杭州市西溪医院建档的738名孕妇及其婴儿作为研究对象,收集母孕期和婴儿早期钙剂和维生素D的补充状况,将孕妇分为钙剂补充组(补充时间不少于12周)和未补充组,婴儿分为钙剂和维生素D同补组、单补维生素D组、单补钙剂组,计算婴儿出生时和6月龄时BMI值,比较各组6月龄时肠道菌群构成。结果母孕期钙剂补充组婴儿刚出生身体质量指数(BMI)[(13.98±1.47)kg/m2 vs.(17.91±1.23)kg/m2]和6月龄时BMI[(12.64±1.24)kg/m2 vs.(16.72±0.92)kg/m2]均高于母孕期未补充钙剂组,t值分别为5.574、6.009,均P<0.05;母孕期补充钙剂组内,单补钙剂组婴儿6月龄BMI[(18.63±0.52)kg/m2]高于单补维生素D组[(17.58±1.18)kg/m2]、钙剂和维生素D同补组[(17.88±0.69)kg/m2],t值分别为6.924、5.593,均P<0.05;母孕期未补充钙剂组内,单补钙剂组BMI[(18.32±3.20)kg/m2]高于单补维生素D组[(17.81±1.33)kg/m2]、钙剂和维生素D同补组[(17.63±1.21)kg/m2],t值分别为5.584、4.679,均P<0.05;不同婴儿早期钙剂补充组中,单纯维生素D补充组的双歧杆菌属水平明显低于单补钙剂组(t=10.663)及钙剂和维生素D同补组(t=9.493),乳酸菌属菌群水平明显高于单补钙剂组(t=13.173)及钙剂和维生素D同补组(t=18.905),差异均有统计学意义(均P<0.05)。结论母孕期摄入适量的钙有利于胎儿生长发育,但婴儿早期补充钙剂可引起BMI增加过快,并促进肠道乳酸菌属生长。Objective To explore the effect of calcium supplementation during pregnancy and early infancy on intestinal flora of neonates.Methods During the period from March 2017 to September 2017,738 pregnant women and their infants registered in our hospital were selected as subjects of study.Supplementation status of calcium and vitamin D during pregnancy and early infancy were collected.Pregnant women were divided into calcium supplementation group(supplementation time was no less than 12 weeks) and non-supplementation group.Infants were divided into calcium supplementation group,vitamin D supplementation group,vitamin D combined calcium supplementation group.BMI at birth and 6 months were measured.Intestinal flora composition of each group at 6 months were detected and compared.Results BMI values at birth and 6 months in calcium supplementation group [(13.98±1.47,17.91±1.23)kg/m^2] were higher than those in non-calcium supplementation group [(12.64±1.24、16.72±0.92) kg/m^2](t=5.574,6.009,respectively,P<0.05 for both).In calcium supplement group during pregnancy,BMI value at 6 month in calcium supplement group [(18.63±0.52) kg/m^2] was higher than that in vitamin D supplement group,calcium combined vitamin D supplement group [(17.58±1.18,17.88±0.69) kg/m^2](t=6.924,5.593,respectively,P<0.05 for both).In the group without calcium supplement during pregnancy,BMI value at 6 month in calcium supplement group [(18.32±3.20) kg/m^2] was higher than that of vitamin D supplement group,calcium combined vitamin D supplement group [(17.81±1.33,17.63±1.21) kg/m^2](t=5.584,4.679,P<0.05).The level of Bifidobacterium in calcium supplement group was markedly lower than that of calcium supplement group(t=10.663) and calcium and vitamin D combined supplement group(t=9.493),while the level of Lactobacillus was considerably higher than calcium supplement group(t=13.173) and calcium and Vitamin D combined supplement group(t=18.905),and the differences for them all showed statistical significance(P<0.05 for all).Conclusion Adequate

关 键 词：母孕期 婴儿早期 钙剂 维生素D 肠道菌群 

分 类 号：R714.7[医药卫生—妇产科学]