羟考酮在术后硬膜外镇痛中的应用  

Application of oxycodone in post-operative epidural analgesia

作　　者：谢凯[1] 李玉红[1,2] XIE kai;LI Yu-hong(Department of Anesthesiology,Shaoxing People's Hospital,Shaoxing ZHEJIANG 312000,China;Clinical Research Center,Shaoxing People's Hospital,Shaoxing ZHEJIANG 312000,China)

机构地区：[1]绍兴市人民医院麻醉科,浙江绍兴312000 [2]绍兴市人民医院医学研究中心,浙江绍兴312000

出　　处：《中国新药与临床杂志》2019年第12期711-715,共5页Chinese Journal of New Drugs and Clinical Remedies

基　　金：浙江省科学技术厅公益性技术应用研究项目（LGF19H030011）;浙江省卫计委医药卫生科技计划（2018KY173）;绍兴市科技局公益性技术应用研究计划（2017B70038）;绍兴市麻醉学重点学科（2019SZD04)

摘　　要：羟考酮为阿片μ受体和κ受体激动药,可以通过静脉或硬膜外给药。羟考酮硬膜外给药可增加局麻药的镇痛效果,减少胎儿体内代谢产物的蓄积。目前羟考酮硬膜外镇痛多用于剖宫产或者腹部手术术后镇痛,与局麻药具有协同作用,镇痛效果佳,患者不良反应发生率低、程度轻。羟考酮硬膜外给药合适剂量及其敏感性的影响因素需要进一步探讨。Oxycodone is an opioidμandκreceptor agonist,which can be administered intravenously or epidurally.Epidural oxycodone can increase the analgesic effect of local anesthetics and reduce their accumulation of metabolites in the fetus.At present,epidural oxycodone is common used for analgesia after cesarean or abdominal surgery,which has synergistic effect with local anesthetics,good analgesic effect and low incidence of adverse reactions.Influencing factors of appropriate dosage and sensitivity of oxycodone for epidural administration need to be further explored.

关 键 词：羟考酮 疼痛 手术后 镇痛 硬膜外 

分 类 号：R971[医药卫生—药品]