2?3?4?5-四苯基环戊-2?4-二烯酮的合成工艺研究  

Study on the synthesis of 2?3?4?5-tetraphenylcyclopenta-2?4-dienone

作　　者：李雪枫[1] 方芙容 祝婷婷 杨谊 刘斌[1,2] LI Xue-feng;FANG Fu-rong;ZHU Ting-ting;YANG Yi;LIU Bin(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xi'an 712046,China;Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xi'an 712046,China)

机构地区：[1]陕西国际商贸学院医药学院,陕西西安712046 [2]陕西省中药绿色制造技术协同创新中心,陕西西安712046

出　　处：《精细与专用化学品》2019年第12期28-31,共4页Fine and Specialty Chemicals

基　　金：2019年陕西省大学生创新创业项目(S201913123011);陕西国际商贸学院“中药药效物质研究”创新团队(SSY18TD01)

摘　　要：以1,3-二苯基丙酮和二苯基乙二酮为原料,无水乙醇为溶剂,在氢氧化钾(KOH)作用下经过2次Aldol缩合-消除反应,得到2,3,4,5-四苯基环戊-2,4-二烯酮。产物结构通过~1HNMR和ESI-MS鉴定。确定的最佳反应工艺条件为:n(二苯基乙二酮)∶n(1?3-二苯基丙酮)=1.1∶1,n(KOH)∶n(1,3-二苯基丙酮)=1∶4,反应温度为78℃,反应时间为50min。在此最佳条件下,产物的收率为88.5%。2,3,4,5-Tetraphenylcyclopenta-2,4-dienone was synthesized from 1,3-diphenylpropan-2-one and benzil in absolute ethanol by Aldol condensation-elimination reaction twice in the presence of KOH as base.The structure of the product was confirmed by^1HNMR and ESI-MS.The optimal reaction conditions of were also investigated:the mole ratio of 1,3-diphenylpropan-2-one and benzil was 1.1∶1,the amount of KOH was n(KOH)∶n(1,3-diphenylpropan-2-one)=1∶4,the reaction temperature was 78℃,the reaction time was 50 min.Target compound was obtained in a yield of 88.5%by the optimal reaction conditions.

关 键 词：四苯基环戊二烯酮 ALDOL缩合反应 消除反应 合成 

分 类 号：TQ463􀀁[化学工程—制药化工]