孕中期超声检测子宫动脉血流参数联合母血清β-HCG、AFP在妊娠期高血压疾病中的价值分析  

Analysis of the value of uterine artery blood flow parameters and maternal serum β-hCG, AFP detected by ultrasonography in the second trimester of pregnancy in hypertensive disorder complicating pregnancy

作　　者：刘美冰 冯智君 郭秋燕 廖细芳 郑木如 LIU Mei-bing;FENG Zhi-jun;GUO Qiu-yan(Department of Ultrasonography,Zengcheng District Maternal and Child Health HAospital,Guangzhou 511300,China)

机构地区：[1]增城区妇幼保健院超声科

出　　处：《中国实用医药》2019年第36期17-19,共3页China Practical Medicine

基　　金：广州市卫生计生科技一般引导项目(项目编号:20171A010343)

摘　　要：目的分析孕中期超声检测子宫动脉血流参数[子宫动脉搏动指数(PI)、子宫动脉阻力指数(RI)]联合母血清β-人绒毛膜促性腺激素(β-HCG)、甲胎蛋白(AFP)在妊娠期高血压疾病中的应用价值。方法选取460例孕妇作为研究对象,所有孕妇均观察追踪随访至产后12周,并依据妊娠结局分为妊高症组(80例)和对照组(380例)。两组孕妇均行子宫动脉超声检测子宫动脉血流参数,并抽取肘前静脉血清检测母血β-HCG、AFP水平。比较两组孕妇子宫动脉血流参数、母血清β-HCG、AFP水平。结果妊高症组孕妇的母血清β-HCG、AFP水平分别为(28786.8±313.3)IU/L、(194.5±53.2)ng/L,均明显高于对照组的(25650.3±410.2)IU/L、(183.2±41.6)ng/L,差异均具有统计学意义(P<0.05)。妊高症组孕妇的RI、PI值分别为(0.72±0.09)、(1.32±0.30),均明显高于对照组的(0.63±0.09)、(0.89±0.14),差异均具有统计学意义(P<0.05)。结论孕妇在孕中期行子宫动脉血流参数联合母血清β-HCG、AFP检测,有助于及时发现妊娠期高血压疾病的发生,值得临床推广应用。Objective To analyze the value of uterine artery blood flow parameters[uterine artery pulsation index(PI),uterine artery resistance index(RI)]combined with maternal serumβ-human chorionic gonadotropin(β-HCG)andα-fetoprotein(AFP)detected by ultrasound in the second trimester of pregnancy in hypertensive disorder complicating pregnancy.Methods A total of 460 pregnant women were selected as the research subjects,and all of them were followed up to 12 weeks postpartum.They were divided into pregnancyinduced hypertension group(80 cases)and control group(380 cases)according to pregnancy outcomes.The uterine artery blood flow parameters were detected by ultrasound in both groups,and the maternal bloodβ-hCG and AFP levels were detected by blood sampling from anterior cubital vein blood.The uterine artery blood flow parameters,maternal serumβ-hCG and AFP levels were compared between the two groups.Results The maternal serumβ-HCG and AFP was(28786.8±313.3)IU/L and(194.5±53.2)ng/L in pregnancy-induced hypertension group,which was obviously higher than(25650.3±410.2)IU/L and(183.2±41.6)ng/L in the control group,and their difference was statistically significant(P<0.05).The RI and PI value was(0.72±0.09)and(1.32±0.30)in pregnancy-induced hypertension group,which was obviously higher than(0.63±0.09)and(0.89±0.14)in the control group,and their difference was statistically significant(P<0.05).Conclusion The detection of uterine artery blood flow parameters combined with maternal serumβ-hCG and AFP in the second trimester of pregnancy is helpful to detect the occurrence of hypertensive disorder complicating pregnancy in time,which is worthy of clinical promotion and application.

关 键 词：妊娠期高血压 子宫动脉搏动指数 子宫动脉阻力指数 血清β-人绒毛膜促性腺激素 甲胎蛋白 

分 类 号：R71[医药卫生—妇产科学]