骨界面组织工程治疗韧带与肌腱损伤研究进展  

Research progress in bone interface tissue engineering for ligament and tendon injury

作　　者：李稚君[1] 张华峰[1] 李晖[1] Li Zhijun;Zhang Huafeng;Li Hui(Department of Orthopaedics,General Hospital of Tianjin Medical University,Tianjin 300051,China)

机构地区：[1]天津医科大学总医院骨科,300051

出　　处：《国际生物医学工程杂志》2019年第5期436-440,共5页International Journal of Biomedical Engineering

摘　　要：韧带、肌腱与骨的结合部位容易受到损伤,往往不能自行愈合,甚至在手术后也无法取得良好预后。界面组织工程是一种通过功能连接软、硬组织,再生原始解剖功能和结构的综合策略,从而提高临床疗效。对界面组织工程和复合组织再生在软组织愈合机理进行系统化综述。针对治疗从两种常见软组织-骨连接(韧带骨连接,肌腱骨连接)结构损伤为基础综述了界面工程的新进展及从单一组织到复合组织结构的发展。总结了近些年的最新界面组织工程创新结构设计和潜在的临床应用。就未来的研究而言,对界面发育、再生和内环境平衡的机制、结构-功能关系及驱动界面发育、再生和内环境平衡的生物学过程等方面的深入研究仍是十分必要的。这些创新研究推动了组织工程与临床结合的意义,并在复杂组织的构建以致未来全关节的再生均具有更广泛的意义。The interface of ligaments,tendons,and bones are susceptible to damage,often fail to heal themselves,and even cannot achieve a good prognosis after surgery.Interface tissue engineering is a comprehensive strategy to functionally connect soft and hard tissues to regenerate original anatomical functions and structures,thereby improving clinical efficacy.In this paper,the interface tissue engineering and composite tissue regeneration in soft tissue healing were systematically reviewed.The recent advances in interface engineering were summarized,based on the treatment of structural damage from two common soft tissue-bone connections(ligamentous bone connections,tendon bone connections),from the development of single tissue to composite tissue structures.The latest interface tissue engineering innovation structure design and potential clinical applications in recent years were reviewed.For future research,in-depth research on the mechanisms of interface development,regeneration,and internal environment balance,structure-function relationships,and biological processes that drive interface development,regeneration,and internal environment balance are still necessary.The innovative studies on interface tissue engineering have promoted the significance of the integration of tissue engineering and clinical,and the construction of complex tissues,so that it has broader significance for the future regeneration of total joints.

关 键 词：生物材料 肌腱 韧带 组织工程 软硬组织修复 

分 类 号：R68[医药卫生—骨科学]