血液灌流治疗内毒素血症机理及研究进展  

Mechanism and research status of hemoperfusion in endotoxemia treatment

作　　者：李依宸 刘娟娟 郭红星 李涛[1,2] Li Yichen;Liu Juanjuan;Guo Hongxing;Li Tao(Ministry of Health Artificial Cell Engineering Research Center,Tianjin Key Laboratory of External Life Support for Severe Diseases,Tianjin Third Central Hospital,Tianjin 300170,China;Tianjin Key Laboratory of Hemoperfusion Technology Enterprises,Tianjin Zibo High-Tech Co.,Ltd.,Tianjin 300170,China)

机构地区：[1]卫生部人工细胞工程技术研究中心,天津市重症疾病体外生命支持重点实验室,天津市第三中心医院,300170 [2]天津市血液灌流技术企业重点实验室,天津市紫波高科技有限公司,300170

出　　处：《国际生物医学工程杂志》2019年第5期441-445,共5页International Journal of Biomedical Engineering

基　　金：天津市科技支撑重点研究计划项目(15ZCZDGX00280);天津市卫生局攻关项目(13KG112);天津市创新平台与人才专项(16PTSYJC00210)。

摘　　要：内毒素血症是由于血液中细菌或病灶内细菌释放出大量内毒素至血液而引起的一种病理生理表现。其会引起多器官衰竭、发生不可逆休克甚至造成死亡,具有较高的死亡率。细菌内毒素则是引起内毒素血症的主要因素,目前临床上尚缺乏安全有效的药物用于治疗内毒素血症。研究结果表明,通过血液净化方法可有效降低血液中内毒素水平,从而达到治疗内毒素血症的目的。探讨了内毒素血症的致病机理,介绍了血液灌流治疗技术的发展,不同血液灌流吸附树脂吸附内毒素的机理和研究现状以及用于治疗内毒素血症的血液灌流吸附材料的性能和安全性要求,旨在为治疗内毒素血症合成新型血液灌流吸附材料提供理论支持。Endotoxemia is a pathophysiological manifestation caused by the release of large amounts of endotoxin from bacteria in the blood or in the lesion.It can cause multiple organ failure,irreversible shock,and even death.The mortality rate of endotoxemiaIt is high.Bacterial endotoxin is the main cause of endotoxemia.At present,there is no safe and effective drug to treat endotoxemia in clinic.Research shows that blood purification can effectively reduce endotoxin level in the blood,then achieve the goal of treatment of endotoxemia.In this paper,the pathogenesis of endotoxemia,the development of hemoperfusion therapy technology,the mechanism and research status of endotoxin adsorption by different hemoperfusion resin were discussed,and the performance and safety requirements of hemoperfusion adsorbent materials for endotoxemia treatment were studied,so as to provide theoretical support for the synthesis of new hemoperfusion adsorption materials for the treatment of endotoxemia.

关 键 词：血液灌流 内毒素血症 吸附机理 

分 类 号：R28[医药卫生—中药学]