小儿支气管肺炎血清C反应蛋白、血清D-二聚体的表达水平及临床意义  

The expression level and clinical significance of serum C-reactive protein and serum D-dimer in children with bronchopneumonia

作　　者：李晓明[1] 宋春华[1] 宋卫娜[1] Li Xiaoming;Song Chunhua;Song Weina(Deparlment of Pediatrics,Dezhou People's Hospital,Dezhou 253000,China)

机构地区：[1]德州市人民医院儿科,山东德州253000

出　　处：《中国临床实用医学》2019年第6期9-12,共4页China Clinical Practical Medicine

摘　　要：目的探讨小儿支气管肺炎血清C反应蛋白、血清D-二聚体的表达水平及临床意义.方法选取2015年3月至2017年3月德州市人民医院儿科收治的50例小儿支气管肺炎患儿作为支气管肺炎组,另选择同时期健康体检小儿50例作为健康组,支气管肺炎组男26例,女24例,年龄(4.89±0.11)岁,年龄范围为3~6岁,健康组男25例,女25例,年龄(5.02±1.02)岁,年龄范围为2~7岁.比较治疗前两组血清C反应蛋白、血清D-二聚体的表达水平,观察支气管肺炎组患儿治疗前后对比治疗前后的血清C反应蛋白、血清D-二聚体的表达水平.结果治疗前支气管肺炎组血清C反应蛋白[(118.34±1.34)mg/L]、血清D-二聚体[(4.23±0.92)mg/L]的表达水平高于健康组[(60.45±1.45)mg/L、(2.76±0.08)mg/L],差异有统计学意义(P<0.05).支气管肺炎组患儿治疗后显效28例,有效18例,无效4例,有效率为92.0%(46/50).支气管肺炎组治疗第3天[(91.45±1.84)mg/L]、第7天[(75.39±1.53)mg/L]血清C反应蛋白的表达水平均低于第1天[(106.34±1.93)mg/L],第7天血清C反应蛋白的表达水平低于第3天;支气管肺炎组治疗第3天[(3.67±0.45)mg/L]、第7天[(2.98±0.62)mg/L]血清D-二聚体的表达水平均低于第1天[(4.02±0.91)mg/L],第7天血清D-二聚体的表达水平低于第3天,差异均有统计学意义(P<0.05).结论血清C反应蛋白、血清D-二聚体的表达在小儿支气管肺炎患儿中具有较高的诊断价值,能够用于判断并对患儿的预后进行评价.Objective To investigate the expression of serum C-reactive protein and serum D-di-mer in children with bronchopneumonia and analyze its clinical significance.Methods The 50 cases of children with bronchopneumonia who were admitted from March 2015 to March 2017 were divided into the bronchopneumonia group,and 50 cases of children with physical examination in the same period were divid-ed into the healthy group.In the bronchopneumonia group,26 males and 24 females were(4.89±0.11)years old,ranging from 3 to 6 years old;in the healthy group,25 males and 25 females were(5.02±1.02)years old,ranging from 2 to 7 years old.The expression levels of serum C-reactive protein and serum D-di-mer in the two groups before and after treatment were compared.Results The expression levels of serum C-reactive protein[(118.34±1.34)mg/L]and serum D-dimer[(4.23±0.92)mg/L]in the broncho-pneumonia group before treatment were higher than those in the healthy group[(60.45±1.45)mg/L and(2.76±0.08)mg/L],with statistically significant differences(P<0.05).In the bronchopneumonia group,28 cases were effective,18 cases were effective,4 cases were ineffective,the effective rate was 92.0%(46/50).On day 3[(91.45±1.84)mg/L]and day 7[(75.39±1.53)mg/L],the expression level of serum C-reactive protein in the bronchopneumonia group was lower than that on day 1[(106.34±1.93)mg/L],and the expression level of serum C-reactive protein on day 7 was lower than that on day 3.On day 3[(3.67±0.45)mg/L]and day 7[(2.98±0.62)mg/L],the expression level of serum D-di-mer in the bronchopneumonia group was lower than that on day 1[(4.02±0.91)mg/L],and the expres-sion level of serum D-dimer on day 7 was lower than that on day 3,and the difference was statistically sig-nificant(P<0.05).Conclusion The expression of serum C-reactive protein and serum D-dimer has a high diagnostic value in children with bronchopneumonia,which can be used to judge and evaluate the prog-nosis of children.

关 键 词：小儿支气管肺炎 血清C反应蛋白 血清D-二聚体 

分 类 号：R72[医药卫生—儿科]