补体系统在系统性红斑狼疮诊疗中的价值  

Value of complement system in the diagnosis of systemic lupus erythematosus

作　　者：周海舟[1] 关秀茹[1] Zhou Haizhou;Guan Xiuru(Department of Laboratory Diagnosis,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院检验科,哈尔滨150001

出　　处：《中华检验医学杂志》2019年第12期1002-1006,共5页Chinese Journal of Laboratory Medicine

摘　　要：补体系统在系统性红斑狼疮(SLE)发病中发挥重要作用。目前在国际公认的SLE分类标准中,补体成分3(C 3)、补体成分4(C4)作为SLE免疫学诊断指标之一。尽管补体C3和C4对系统性红斑狼疮的诊断有一定的价值,但它们并不是SLE非常特异的诊断指标。因而,需要发现更多有诊疗价值的指标。本文探讨了补体系统在系统性红斑狼疮研究的新进展,补体水平、细胞结合的补体激活产物及膜结合性补体调节蛋白均与SLE的发病有关,可有望成为SLE的诊断、预测转归的新型生物标志物。The complement system plays a major role in systemic lupus erythematosus(SLE).At present,complement component 3(C3)and component 4(C4)are the diagnostic markers in the internationally recognized standard of SLE classification.Complement C3 and C4 can play a role in the diagnosis of SLE patients,but they are not very specific diagnostic markers.Therefore,it is important to find more better biomarkers of SLE.In this review,the latest findings in complement-focused research in SLE were explored.Complement level,cell-bound complement activation products and membrane-bound complement regulatory proteins are associated with the pathogenesis of SLE.They may become SLE biomarkers and aid the diagnosis and monitoring of patients with this disease.

关 键 词：红斑狼疮 系统性 补体激活 补体系统蛋白质类 生物标记 

分 类 号：R59[医药卫生—内科学]