雌激素联合孕激素对功能失调性子宫出血患者子宫动脉血流动力学及子宫内膜微血管密度和血清因子的影响  

Impact of estrogen and progestogen on uterine hemodynamics,endometrial microvascular density and serum factors in patients with dysfunctional uterine bleeding

作　　者：王丽 WANG Li(Wafangdian second hospital limited company,Dalian 116314,China)

机构地区：[1]瓦房店第二医院有限公司

出　　处：《临床合理用药杂志》2019年第33期20-21,23,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨雌激素联合孕激素对功能失调性子宫出血(功血)患者子宫动脉血流动力学、子宫内膜微血管密度及血清因子的影响。方法选取瓦房店第二医院有限公司2015年8月-2017年8月收治的功血患者82例,根据治疗方法不同分为对照组与研究组,各41例。对照组予以孕激素治疗,研究组予以雌激素联合孕激素治疗,两组均持续用药至止血后20 d。比较两组子宫血流动力学指标(子宫动脉阻力指数、搏动指数、血流量、平均流速),子宫内膜微血管密度、血清因子〔血栓素A2(TXA2)/前列环素(PGI2)、抑制素B(INHB)、抗甲状腺过氧化物酶抗体(TPOAb)〕。结果治疗前两组子宫动脉阻力指数、搏动指数、血流量、平均流速比较,差异无统计学意义(P>0.05);治疗后研究组子宫动脉阻力指数低于对照组,子宫动脉搏动指数、血流量、平均流速高于对照组(P<0.05)。治疗前两组子宫内膜微血管密度、TXA2/PGI2、INHB、TPOAb比较,差异无统计学意义(P>0.05);治疗后研究组子宫内膜微血管密度、TXA2/PGI2、INHB高于对照组,TPOAb低于对照组(P<0.05)。结论雌激素联合孕激素治疗功血,可改善患者子宫动脉血流动力学,提高子宫内膜微血管密度,改善血清因子水平。Objective To study the impact of estrogen and progestogen on uterine hemodynamics,endometrial microvascular density and serum factors in patients with dysfunctional uterine bleeding(DUB).Methods A total of 82 cases of patients with DUB were selected from August 2015 to August 2017 in Wafangdian second hospital limited company,which were divided into control group and study group according to different treatment methods,41 cases in each group.The control group was treated with progestogen,the study group was treated with estrogen combined with progestogen,the two groups continued to take medicine until 20 days after hemostasis.Uterine hemodynamic index(uterine artery resistance index, pulsatility index, blood flow, average flow rate),endometrial microvessel density,serum factors(TXA2/PGI2,INHB,TPOAb)were compared between the two groups.Results Before treatment,there was no significant difference in uterine artery resistance index,pulsatility index,blood flow and average flow rate between the two groups(P>0.05);after treatment,the study group of uterine artery resistance index was lower than control group,and the pulsatility index,blood flow and average flow rate were higher than control group(P<0.05).Before treatment,there was no significant difference in endometrial microvessel density,TXA2/PGI2,INHB,TPOAb between the two groups(P>0.05);after treatment,the study group of endometrial microvessel density,TXA2/PGI2,INHB were higher than control group,and TPOAb was lower than control group(P<0.05).Conclusion Estrogen and progestogen have obvious effects in DUB patients,which can remarkably improve the uterine hemodynamics, endometrial microvessel density and serum factors.

关 键 词：功能失调性子宫出血 雌激素 孕激素 子宫血流动力学 子宫内膜微血管密度 血清因子 

分 类 号：R711.52[医药卫生—妇产科学]