贯叶金丝桃中一个新的2,3-二氧代黄酮  

A new 2,3-dioxoflavonoid from the aerial part of Hypericum perforatum

作　　者：马洁 吉腾飞 田晋 王彦改 杨建波 苏亚伦 王爱国 MA Jie;JI Teng-fei;TIAN Jin;WANG Yan-gai;YANG Jian-bo;SU Ya-lun;WANG Ai-guo(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室

出　　处：《药学学报》2019年第12期2286-2288,共3页Acta Pharmaceutica Sinica

基　　金：北京市自然科学基金青年项目(7194299);中国医学科学院医学与健康科技创新工程(CAMS-I2M-1-010)

摘　　要：利用硅胶柱色谱、Sephedax LH-20、制备高效液相色谱等分离、纯化方法,从贯叶金丝桃(Hypericum perforatum L.)中分离得到一个新的黄酮类化合物,其结构经UV、IR、MS、HR-ESI-MS及核磁共振等波谱技术鉴定为:Rel-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2-methoxy-3-(2-oxopropyl)chroman-4-one(1)。化合物1是一个含有一个丙酮基的2,3-二氧代黄酮类化合物,在自然界中较为罕见。此外,还对该化合物的可能生源途径进行了推测。Phytochemical study of the aerial parts of Hypericum perforatum L.resulted in the isolation of an undescribed compound,which was identified as Rel-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2-methoxy-3-(2-oxopropyl)chroman-4-one(1)by spectroscopic methods including UV,IR,HR-ESI-MS,1D and 2D NMR spectra.Compound 1 is a new 2,3-dioxo-flavone with an acetonyl moiety,rarely found in nature.In addition,a plausible biogenetic pathway of 1 was proposed in this article.

关 键 词：贯叶金丝桃 化学成分 2 3-二氧代黄酮 

分 类 号：R284[医药卫生—中药学]