参苓白术散联合孟鲁司特钠治疗焦炉工哮喘的疗效观察  

Effect observation of Shenling Baizhu Powder combined with montelukast sodium in treatment for coke oven workers with asthma

作　　者：王静 郑丽颖[2] 耿贺梅[3] 刘运秋[2] WANG Jing;ZHENG Li-ying;GENG He-mei;LIU Yun-qiu(Second Department of Neurology,Tangshan Hongci Hospitaly Tangshan Hebei,063000,China;Department of Respiratory M edicine,Kailuan General Hospital,Tangshan H ebei,063000,China;Department of Infection Management,Kailuan General Hospital,Tangshan Hebei,063000,China)

机构地区：[1]唐山弘慈医院神内二科,河北唐山063000 [2]开滦总医院呼吸内科,河北唐山063000 [3]开滦总医院感染管理科,河北唐山063000

出　　处：《职业与健康》2019年第23期3169-3171,3175,共4页Occupation and Health

基　　金：河北省医学科学研究重点课题计划(20171446)

摘　　要：目的探讨参苓白术散联合孟鲁司特钠治疗焦炉工哮喘的疗效。方法选取2015年10月-2017年10月唐山弘慈医院和开滦总医院的焦炉工哮喘患者98例作为研究对象,采用随机数字表法分为两组,对照组49例采用孟鲁司特钠治疗,观察组49例采用参苓白术散联合孟鲁司特钠治疗,于治疗前后行炎症因子[C反应蛋白(CRP)、白细胞介素-17(IL-17)、肿瘤坏死因子α(TNFα)]检测和肺功能评定[第1 s用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC、最大呼气流速峰值(PEF)],比较两组临床疗效及安全性(恶心呕吐、胃肠道反应、过敏反应、肝肾功能指标异常)。结果观察组治疗后炎症因子指标CRP[(7.9±1.5)mg/L]、IL-17[(40.6±5.3)ng/mL]、TNFα[(13.4±2.2)ng/mL]低于对照组[(13.4±2.1)mg/L、(51.2±6.4)ng/mL、(23.1±2.6)ng/mL]。观察组治疗后肺功能指标FEV1[(2.4±0.4)L]、FVC[(2.8±0.6)L]、FEV1/FVC(0.85±0.07)、PEF[(1.7±0.4)L/s]高于对照组[(1.7±0.3)L、(2.4±0.4)L、(0.72±0.09)、(1.5±0.3)L/s]。观察组治疗总有效率(98.0%)高于对照组(83.7%)。差异有统计学意义(P<0.05)。结论参苓白术散联合孟鲁司特钠治疗焦炉工哮喘的疗效显著,可减少患者的炎症和改善肺功能状况。Objective To investigate effect of Shenling Baizhu Powder combined with montelukast sodium in treatment for coke oven workers with asthma.Methods 98 coke oven workers with asthma were selected in Tangshan Hongci Hospital and Kailuan General Hospital from October 2015 to October 2017,who were divided into two groups by random number table method.49 patients in control group were treated with montelukast sodium,and 49 patients in observation group were treated with Shenling Baizhu Powder combined with montelukast sodium.Inflammatory factors[C-reactive protein(CRP),interleukin-17(IL-17),tumor necrosis factorα(TNFα)]test and lung function evaluation[forced expiratory volume in the first second(FEV1),Forced vital capacity(FVC),FEV1/FVC,peak expiratory flow(PEF)]were performed before and after treatment.Clinical efficacy and safety(nausea and vomiting,gastrointestinal reactions,anaphylaxis,liver and kidney function abnormalities)were compared between two groups.Results After treatment,the inflammatory factors indexes[CRP(7.9±1.5)mg/L,IL-17(40.6±5.3)ng/ml,TNFα(13.4±2.2)ng/ml]in observation group were lower than those in control group[(13.4±2.1)mg/L,(51.2±6.4)ng/ml,(23.1±2.6)ng/ml].After treatment,the pulmonary function indexes[FEV1(2.4±0.4)L,FVC(2.8±0.6)L,FEV1/FVC(0.85±0.07),PEF(1.7±0.4)L/s]in observation group were higher than those in control group[(1.7±0.3)L,(2.4±0.4)L,(0.72±0.09),(1.5±0.3)L/s].Total effective rate(98.0%)in observation group was higher than that in control group(83.7%),and the difference was statistically significant(P<0.05).Conclusion Shenling Baizhu Powder combined with montelukast sodium has significan t effect in treatment for coke oven workers with asthma,which can the patient’s inflammation and improve pulmonary function.

关 键 词：参苓白术散 孟鲁司特钠 焦炉工 哮喘 疗效 

分 类 号：R181.3+1[医药卫生—流行病学]