星点设计-效应面法优化双苷清咽含片处方的研究  

Prescription Optimization of Shuangganqingyan Tablet by Central Composite Design-Response Surface Methodology

作　　者：黄云[1] 李学坚[1] 胡文姬[2] 刘布鸣 邱宏聪 HUANG Yun;LI Xuejian;HU Wenji;LIU Buming;QIU Hongcong(Guangxi Scientific Research Center of Chinese Medicine,Nanning,Guangxi,530200,China;Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei,430014,China;Guangxi Quality Standard of Chinese Medicine Research Laboratory,Nanning,Guangxi,530022,China)

机构地区：[1]广西中医药大学科学实验中心,广西南宁530200 [2]武汉市中医医院,湖北武汉430014 [3]广西中药质量标准研究重点实验室,广西南宁530022

出　　处：《广西科学》2019年第5期588-593,共6页Guangxi Sciences

基　　金：广西中药质量标准研究重点实验室开放课题基金项目（GXGZZK201102和桂中重开201507）资助

摘　　要：研究芒果苷、罗汉果甜苷和薄荷脑对双苷清咽含片抗炎药效的贡献,优选出该含片的最优处方。以小鼠腹腔通透性和二甲苯致小鼠耳廓肿胀度为指标,采用星点设计-效应面优化法,研究芒果苷、罗汉果甜苷和薄荷脑的用量对双苷清咽含片抗炎药效的影响。结果表明,对抗炎药效影响的主次顺序为芒果苷>罗汉果甜苷>薄荷脑;星点设计-效应面法优化法给出的优化处方范围为芒果苷占素片片重8.50%~17.50%;罗汉果甜苷占6.37%~13.13%,薄荷脑占0.18%~0.42%;最优处方为芒果苷占素片片重13.00%,罗汉果甜苷占9.75%,薄荷脑占0.30%。应用星点设计-效应面优化法可快速准确地给出双苷清咽含片的最优处方;双苷清咽含片的抗炎药效主要取决于芒果苷和罗汉果甜苷的用量,薄荷脑的用量无显著影响。To study the contribution of mangiferin,mogroside and menthol to the anti-inflammatory effects of Shuangganqingyan tablet(SGQY tablet),it is preferred to prescribe the optimal formulation of this tablet.Mouse auricle tumefaction and abdominal capillary permeability were determined,and central composite design-response surface methodology(CCD-RSM)optimization tests were utilized to study the dosages of mangiferin,mogroside and menthol on the anti-inflammatory effects of SGQY tablet.The results showed that the main order of anti-inflammatory effects was mangiferin>mogroside>menthol.The optimized prescription range given by central composite design-response surface methodology method was that mangiferin accounted for 8.50% to 17.50% of the tablet weight,mogrosides accounted for 6.37%-13.13%,and menthol accounted for 0.18%-0.42%.The optimal prescription was that mogroside occupied accounted for 13.00% of the tablet weight,mogrosides accounted for 9.75%,and menthol accounted for 0.30%.The application of CCD-RSM method can quickly and accurately give the optimal prescription of SGQY tablet.The anti-inflammatory effect of SGQY tablet depends mainly on the amount of mangiferin and mogroside,the amount of menthol used has no significant effect.

关 键 词：双苷清咽含片 抗炎作用 星点设计-效应面优化法 处方优化 

分 类 号：R283.3[医药卫生—中药学]