咳喘平颗粒辅助治疗儿童支气管哮喘发作期的临床观察及对白三烯水平的影响  

Clinical effects of Kechuanping granules in adjuvant therapy for bronchial asthma attack in children and its effect on the level of leukotriene

作　　者：崔何晴 尚莉丽[1] CUI Heqing;SHANG Lili(The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China)

机构地区：[1]安徽中医药大学第一附属医院儿科

出　　处：《中国中西医结合儿科学》2019年第6期483-487,共5页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：安徽省科技攻关项目(1604a0802084);省级重点医院事业发展项目(财社涵[2018]303号)

摘　　要：目的观察咳喘平颗粒治疗支气管哮喘发作期寒性哮喘患儿的临床疗效及对血清白三烯B4(LTB4)、尿液白三烯E4(LTE4)水平的影响。方法选择2017年12月1日至2018年12月31日安徽中医药大学第一附属医院收治的支气管哮喘发作期寒性哮喘患儿60例为研究对象,随机分为观察组31例和对照组29例。对照组予以西医常规治疗,观察组在对照组治疗基础上加用咳喘平颗粒口服。治疗7 d后观察两组患儿临床疗效、中医证候总积分的变化;治疗前后分别采用酶联免疫吸附测定法进行血清LTB4、尿液LTE4水平的测定。结果观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿中医证候总积分显著低于治疗前,差异有统计学意义(P<0.05);治疗后观察组患儿中医证候总积分显著低于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿血清LTB4、尿液LTE4水平显著低于治疗前,差异均有统计学意义(P<0.05);治疗后观察组患儿血清LTB4、尿液LTE4水平显著低于对照组,差异均有统计学意义(P<0.05)。结论咳喘平颗粒可改善支气管哮喘发作期寒性哮喘患儿的中医证候积分,提高临床疗效;咳喘平颗粒可降低支气管哮喘患儿血清LTB4、尿液LTE4水平,其作用机制可能与降低白三烯水平有关。Objective To observe the clinical efficacy of Kechuanping granules in children with cold asthma in the attack of bronchial asthma, and its effect on serum LTB4 and urine LTE4 levels. Methods Sixty children with cold asthma in the attack of bronchial asthma, who were admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from December 1, 2017 to December 31, 2018, were selected as research subjects. They were randomly divided into 31 cases in observation group and 29 cases in control group. The control group was treated with western medicine routinely, and the observation group was treated with Kechuanping granules orally on the basis of the treatment for control group. After 7 days, the changes in the clinical efficacy and TCM syndrome total score of the two groups were observed; the serum LTB4 and urine LTE4 levels were measured by enzyme-linked immunosorbent assay before and after treatment.Results The total clinical effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). After treatment, the total score of TCM syndromes in both groups was significantly lower than that before treatment, and the difference was statistically significant(P<0.05); the total score of TCM syndromes in the observation group was significantly lower than that in the control group after treatment, and the difference was statistically significant(P<0.05). After treatment, the levels of serum LTB4 and urine LTE4 in the two groups were significantly lower than those before treatment, and the difference was statistically significant(P<0.05). After treatment, serum LTB4 and urine LTE4 levels in the observation group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05).Conclusion Kechuanping granules can significantly improve the TCM syndrome scores of children with cold asthma during bronchial asthma attack and improve clinical efficacy. Kechuanp

关 键 词：支气管哮喘 中医证候总积分 咳喘平颗粒 白三烯 儿童 

分 类 号：R725.6[医药卫生—儿科]