EB病毒感染儿童免疫球蛋白及补体变化的临床分析  

Clinical analysis of immunoglobulin and complement changes in children infected with EB virus

作　　者：高健 李玢[1] GAO Jian;LI Fen(Blood Department,Shenyang Children's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市儿童医院血液科

出　　处：《中国中西医结合儿科学》2019年第6期509-511,共3页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的分析EB病毒感染儿童免疫球蛋白及补体变化。方法选择2017年1月1日至2019年6月1日沈阳市儿童医院收治的EB病毒感染患儿100例为研究对象,为观察组,同期选取健康体检儿童100例为对照组,对两组儿童补体水平、血清免疫球蛋白水平使用散射比浊法检测,对比C4、C3、IgE、IgA、IgM、IgG、CD56^+、CD19^+、CD4^+、CD3^+水平。结果观察组患儿IgA与对照组比较,差异无统计学意义(P>0.05);观察组C4、C3、IgE、IgM、IgG显著高于对照组,差异均有统计学意义(P<0.05)。观察组CD56^+、CD19^+、CD3^+显著高于对照组,而CD4^+显著低于对照组,差异均有统计学意义(P<0.05)。结论EB病毒感染和儿童免疫球蛋白具有密切相关性,与CD4^+减少具有明显关系。Objective To analyze the changes of immunoglobulin and complement in children infected with EB virus. Methods From January 1, 2017 to June 1, 2019, 100 children with EBV infection were treated in Shenyang Children’s Hospital, and they were selected as the study subjects(the observation group), and 100 healthy children were selected as the control group at the same time. The complement level and serum immunoglobulin level of children in the two groups were detected by scatter turbidimetry, and the levels of C4, C3, IgE, IgA, IgM, IgG, CD56^+, CD19^+, CD4^+, CD3^+ were compared. Results There was no significant difference in IgA between the observation group and the control group(P>0.05); C4, C3, IgE, IgM and IgG in the observation group were significantly higher than those in the control group(P<0.05). CD56^+, CD19^+ and CD3^+ in the observation group were significantly higher than those in the control group, while CD4^+ was significantly lower than that in the control group(P<0.05).Conclusion Epstein-Barr virus infection is closely related to immunoglobulin in children, and is significantly related to the decrease of CD4^+.

关 键 词：EB病毒感染 免疫球蛋白 补体 儿童 

分 类 号：R725.5[医药卫生—儿科]