瘦素抵抗、瘦素受体基因多态性与冠状动脉粥样硬化性心脏病的相关性进展  

Leptin Resistance,Leptin Receptor Gene Polymorphism and Coronary Atherosclerotic Heart Disease

作　　者：陈元 楚天舒[2] 武力勇[2] CHEN Yuan;CHU Tianshu;WU Liyong(Kunming Medical University Graduate School,Kunming 650000,Yunnan,China;Department of Cardiology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650000,Yunnan,China)

机构地区：[1]昆明医科大学研究生院,云南昆明650000 [2]昆明医科大学第二附属医院心血管内科,云南昆明650000

出　　处：《心血管病学进展》2019年第8期1130-1133,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81860092)

摘　　要：冠状动脉粥样硬化性心脏病(冠心病)是致残致死率很高的疾病之一,近年来有关冠心病与瘦素之间关系的研究越来越多。尤其在肥胖个体中,瘦素抵抗现象与冠心病的发生存在密切联系。目前认为瘦素受体的基因多态性可能在瘦素抵抗现象中发挥重要作用。现对有关文献进行整理并总结了瘦素抵抗、瘦素受体基因多态性与冠心病发病相关研究进展,为冠心病的防治提供一定参考。Coronary atherosclerotic heart disease is one of the diseases with high disability and mortality.In recent years,more and more studies have been conducted on the relationship between coronary atherosclerotic heart disease and leptin.Especially in obese individuals,leptin resistance are closely related to the occurrence of coronary atherosclerotic heart disease.It is believed that the gene polymorphism of leptin receptor may play an important role in leptin resistance.This paper summarizes the research progress of leptin resistance,leptin receptor gene polymorphism and the incidence of coronary atherosclerotic heart disease,and provides some reference for the prevention and treatment of coronary atherosclerotic heart disease.

关 键 词：冠状动脉粥样硬化性心脏病 瘦素 瘦素受体 瘦素抵抗 基因多态性 

分 类 号：R54[医药卫生—心血管疾病]