肾动脉去交感神经术治疗顽固性高血压的研究进展  

Treatment of Resistant Hypertension by Renal Denervation

作　　者：肖蓉雪 刘宗军 XIAO Rongxue;LIU Zongjun(Putuo Center Clinical College,Anhui Medical University,Shanghai 200062,China;Department of Cardiology,Putuo Central Hospital,Shanghai 200062,China)

机构地区：[1]安徽医科大学普陀中心临床学院,上海200062 [2]上海市普陀区中心医院心内科,上海200062

出　　处：《心血管病学进展》2019年第8期1138-1142,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金资助项目(81774076);上海市卫计委临床研究专项(201840247)

摘　　要：高血压是目前导致心脑血管疾病最主要的危险因素之一,因为血压不达标造成的靶器官损伤直接危害人类的健康,而由顽固性高血压引起的心脑血管疾病的发生率和死亡率更高。研究发现,肾脏交感神经过度激活是导致顽固性高血压发生的相关机制之一。1935年Page等发现一种非药物治疗的方法:肾动脉去交感神经术,并对其进行了深入探索,该方法主要通过阻断肾交感传入神经和传出神经活性达到降压的目的,该措施的出现引起了广泛的关注。现就该治疗方法的相关研究进展进行综述。Hypertension is one of the most important risk factors for cardiovascular and cerebrovascular diseases at present,the damage of target organs caused by substandard blood pressure is directly harmful to human health,and the incidence and mortality caused by resistant hypertension is higher.The study found that excessive sympathetic activation of kidney is one of the related mechanisms leading to the development of resistant hypertension.Page et al found a non-drug treatment method-renal denervation in 1935,and explored it deeply.This method mainly aims to reduce blood pressure by blocking renal sympathetic afferent nerve and efferent nerve activity,and the emergence of this method has caused wide concern.This article reviews the related research progress of this treatment.

关 键 词：顽固性高血压 肾动脉去交感神经术 交感神经系统 

分 类 号：R54[医药卫生—心血管疾病]