不同染毒方式构建镍损伤动物模型的研究进展  

Research progress on animal models of nickel-induced damages constructed using different poisoning methods

作　　者：杨晶晶[1] 陈慧[1] YANG Jingjing;CHEN Hui(Lanzhou University Second Hospital and the Second Clinical Medical College,Lanzhou 730000,China)

机构地区：[1]甘肃省兰州市兰州大学第二医院·第二临床医学院

出　　处：《中国实验动物学报》2019年第6期815-820,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(31670518);兰州大学第二医院“萃英科技创新”计划(CY2018-ZD02)~~

摘　　要：镍(nickel)是人类在生活和生产中广泛接触的一种金属元素,是人体必需的微量元素,但其过量蓄积会对人体产生危害。目前镍中毒后对人体造成损伤的机制尚不明确,仍需进一步研究和探讨,而镍损伤中毒模型是研究镍损伤发生机制和治疗的基础。不同镍损伤中毒模型的制备特点不尽相同,应根据不同实验目的来选择不同的实验动物模型,本文对目前常用的几种建模方法进行综述。Nickel is a metal that humans are often exposed to during production and daily life. It is an essential trace element in the human body, but in excess, it can harm the body. The exact mechanism of damage caused by excessive nickel exposure remains unclear, but is related to complex cellular and molecular mechanisms. The model of nickel-induced damages forms the basis for studying the mechanisms treatment of nickel-induced damages. The preparation characteristics of different models of nickel poisoning damage are similar, thus, experimental models should be selected according to the experimental purpose. This paper reviews several commonly used methods of modeling nickel poisoning.

关 键 词：染毒方式 镍损伤 模型构建 

分 类 号：Q95-33[生物学—动物学]