人甲状腺癌细胞株移植免疫缺陷鼠建模的影响因素研究进展  

Analysis of factors influencing the modeling of immunodeficient mouse or rat models transplanted with human thyroid cancer cell lines1

作　　者：朱丽茹 赵德善[1] ZHU Liru;ZHAO Deshan(Department of Nuclear Medicine,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院核医学科,太原030001

出　　处：《中国实验动物学报》2019年第6期821-825,共5页Acta Laboratorium Animalis Scientia Sinica

摘　　要：甲状腺癌在内分泌恶性肿瘤中居于首位。甲状腺癌细胞株移植免疫缺陷鼠模型是人类甲状腺癌的一个缩影,对甲状腺癌的发病机制、药物治疗及131I治疗的机制等研究都有重要的意义。了解和熟知甲状腺癌免疫缺陷鼠建模过程中实验动物选择、关键实验操作,以及明确实验动物碘营养状况和血清促甲状腺激素水平等关键影响因素可以有效提高建模成功率。因此,本文就影响人甲状腺癌细胞株移植免疫缺陷鼠建模成功的相关因素做一简要综述。Thyroid carcinoma ranks first among the malignant endocrine tumors.Immunodeficient mice or rat models of thyroid cancer-cell-line transplantation represent microcosms of human thyroid cancer,which are of great significance for the study of the pathogenesis of thyroid cancer,drug therapy and the mechanism of iodine-131 treatment.Understanding the key influences in the modeling of thyroid cancer immunodeficient mice or rats could improve the success rate of modeling.Therefore,the factors affecting the successful modeling of human thyroid cancer cell-lines in immunodeficient mice and rats are briefly reviewed in this paper.

关 键 词：甲状腺癌 异种移植模型 促甲状腺激素 碘 

分 类 号：Q95-33[生物学—动物学]