左乙拉西坦与拉莫三嗪对伴中央-颞区棘波儿童良性癫■的疗效比较  

Comparison of Treatment Effects Between Levetiracetam and Lamotrigine in Children with Benign Epilepsy of Childhood with Centrotemporal Spikes

作　　者：田丰[1] 乔鑫鑫 TIAN Feng;QIAO Xinxin(Department of Physical Examination,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473058,China;Nanyang Medical College,Nanyang 473058,China)

机构地区：[1]南阳医学高等专科学校第一附属医院体检科

出　　处：《医药导报》2020年第1期55-58,共4页Herald of Medicine

摘　　要：目的比较左乙拉西坦(LEV)和拉莫三嗪(LTG)单药方案对伴中央-颞区棘波(BECTs)儿童良性癫■P300潜伏期及认知功能的影响。方法 BECTs患儿130例,用随机数字表法分为LEV组和LTG组,每组各65例,LEV组患儿给予LEV 500~1500 mg,每天2次,口服;LTG组患儿给予LTG 25~200 mg,每天1或2次,口服,两组均连续治疗6个月。比较两组患儿的临床疗效、P300潜伏期、认知功能和不良反应。结果两组患儿治疗前认知功能评分均相近(P>0.05),治疗后两组患儿的言语量表智商、评定操作量表智商和全量表智商认知功能评分均较治疗前明显上升(P<0.01),组间差异无统计学意义(P>0.05);两组患儿P300潜伏期治疗前相近(P>0.05),治疗后均较治疗前明显下降(P<0.05),组间差异无统计学意义(P>0.05);两组患儿嗜睡、皮疹、食欲减退、恶心呕吐、头晕、记忆力减退、烦躁易怒等不良反应发生率均差异无统计学意义(均P>0.05)。结论 LEV与LTG单药方案对BECTs患儿的临床疗效相当,均能够有效抑制癫样放电,缩短P300潜伏期,改善认知功能,且不良反应相近,安全性较好,而LTG治疗成本相对较低。Objective To investigate the effect of levetiracetam(LEV)and lamotrigine(LTG)monotherapy on P300 latency and cognitive function in children with benign epilepsy of childhood with centrotemporal spikes(BECTs).Methods A total of 130 BECTs children were divided into LEV group and LTG group(65 cases in each group)by random number table method.Children in LEV group were treated with LEV(500-1500 mg,bid,po),and the children in LTG group were treated with LTG(25-200 mg,qd or bid,po).Both groups received continuous treatment for 6 months.The clinical efficacy,P300 latency,cognitive function and adverse reactions of the two groups were compared.Results There was no statistically significant difference in the grade of clinical efficacy between the two groups(P>0.05).The cognitive function scores of the children in the two groups before treatment were similar(P>0.05),and the scores of both two groups significantly increased after treatment(P<0.05).There was no statistically significant difference in cognitive function score between the two groups after treatment(P>0.05).The P300 incubation period of children in the two groups before treatment was similar(P>0.05),and the P300 incubation period of children in the two groups after treatment was significantly lower than that before treatment(P<0.05).There was no statistically significant difference between the two groups(P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups,such as drowsiness,rash,anorexia,nausea and vomiting,dizziness,memory loss or irritability(P>0.05).Conclusion LEV and LTG monotherapy have similar clinical efficacy in BECTS children.Both LEV and LTG monotherapy can effectively inhibit epileptic discharge,shorten P300 incubation period and improve cognitive function.In addition.Both LEV and LTG monotherapy have similar adverse reactions and show good safety.LTG is more affordable and the cost of treatment is relatively low.

关 键 词：左乙拉西坦 拉莫三嗪 中央-颞区棘波 儿童良性癫■ 认知功能 

分 类 号：R971.6[医药卫生—药品] R742.1[医药卫生—药学]