HBV诱导的髓源性抑制细胞亚群及其在慢性HBV感染中的作用  

Role of hepatitis B virus-induced myeloid-derived suppressor cell subsets in chronic HBV infection

作　　者：邬志惠 杨苗苗 涂正坤[1] WU Zhihui;YANG Miaomiao;TU Zhengkun(Research Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学第一医院转化医学研究院

出　　处：《临床肝胆病杂志》2019年第12期2783-2787,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81373143,81571535)

摘　　要：HBV是一种嗜肝性DNA病毒,HBV感染不会引起直接的肝细胞病变,宿主免疫应答决定了病毒能否被清除,同时也是导致HBV相关肝脏疾病的主要原因。髓源性抑制细胞(MDSC)是一群起源于骨髓的非淋巴免疫抑制性细胞,多种病理条件下调节固有和获得性免疫应答。研究发现慢性乙型肝炎患者外周血中MDSC明显高于健康人群,主要介绍了HBV诱导的MDSC亚群在HBV持续感染和肝脏病理学机制中的作用。Hepatitis B virus(HBV)is a member of hepadnavirus,and HBV infection may not cause direct hepatocyte lesions.Host immune response determines whether the virus can be eliminated and is a major cause of HBV-related liver diseases.Myeloid-derived suppressor cells(MDSCs)are a group of non-lymphoid immune suppressor cells originating from bone marrow and can regulate innate and adaptive immune responses under different pathological conditions.Studies have shown that chronic hepatitis B patients have a significantly higher number of MDSCs in peripheral blood than the healthy population.This article introduces the role of HBV-induced MDSC subsets in persistent HBV infection and liver pathological mechanism.

关 键 词：乙型肝炎病毒 髓源性抑制细胞 乙型肝炎 慢性 免疫 细胞 T淋巴细胞 

分 类 号：R512.62[医药卫生—内科学]