利心丸对急性失代偿性心力衰竭患者炎症因子水平的影响  

The Effect of Lixin Pill on Inflammatory Factor Level in Patients with Acute Decompensated Heart Failure

作　　者：龚文学 尹锐 熊曙光 GONG Wen-xue;YIN Rui;XIONG Shu-guang(Emergency Department,The Second Affiliated Hospital of Chengdu Medical College,416 Hospital of Nuclear Industry,Chengdu 614000,China;Cardiovascular Medicine Department,The Second Affiliated Hospital of Chengdu Medical College,416 Hospital of Nuclear Industry,Chengdu 614000,China;Respiratory Medicine Department,The Second Affiliated Hospital of Chengdu Medical College,416 Hospital of Nuclear Industry,Chengdu 614000,China)

机构地区：[1]成都医学院第二附属医院,核工业四一六医院急诊科,成都614000 [2]成都医学院第二附属医院,核工业四一六医院心血管内科,成都614000 [3]成都医学院第二附属医院,核工业四一六医院呼吸内科,成都614000

出　　处：《标记免疫分析与临床》2019年第11期1925-1928,共4页Labeled Immunoassays and Clinical Medicine

基　　金：成都市卫生和计划生育委员会科研课题(编号:2015179)

摘　　要：目的探讨利心丸对急性失代偿性心力衰竭患者炎症因子水平的影响。方法选择2009年1月至2014年1月我院收治的急性代偿性心力衰竭患者94例,采用随机数字表法分为两组,各47例。对照组实施常规治疗,观察组于常规治疗基础上加用利心丸治疗。治疗前与治疗14 d后,比较两组心功能指标、炎症指标、中医症状积分。结果治疗前,两组左心室舒张末期容积(left ventricular end-diastolic volume,LVEDV)、左心室射血分数(left ventricular ejection fractions,LVEF)、左心室短轴缩短率(left ventricular fractional shortening,LVFS)比较,差异无统计学意义(P>0.05);两组治疗后LVEDV值均降低,LVEF及LVFS值均升高,且观察组治疗后LVEDV低于对照组,LVEF及LVFS高于对照组,差异有统计学意义(P<0.05);两组治疗前肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin 6,IL-6)、白细胞介素-8(interleukin 8,IL-8)、白细胞介素-10(interleukin 10,IL-10)、血浆N末端B型脑钠肽前体(N terminal pro brain natriuretic peptide,NT-proBNP)及肌钙蛋白(cardiac troponin,cTnT)水平比较,差异无统计学意义(P>0.05);两组治疗后TNF-α、IL-6、IL-8、NT-proBNP及cTnT水平均降低,IL-10水平均升高,且观察组治疗后TNF-α、IL-6、IL-8、NT-proBNP及cTnT水平低于对照组,IL-10水平高于对照组,差异有统计学意义(P<0.05);两组治疗前中医症状积分比较,差异无统计学意义(P>0.05);两组治疗后中医症状积分均下降,且观察组治疗后中医症状积分低于对照组,差异有统计学意义(P<0.05)。结论利心丸治疗急性失代偿性心力衰竭可在一定程度上改善患者心功能,缓解炎症反应,挽回心肌损伤,促进患者症状恢复。Objective To explore the effect of Lixin Pill on inflammatory factors in patients with acute decompensated heart failure.Methods Ninety-four patients with acute compensatory heart failure admitted to our hospital from January,2009 to January,2014 were selected and divided into two groups by random number table,with 47 cases in each group.The control group received the routine treatment,while the observation group was treated with Lixin Pill on the basis of the routine treatment.Before the treatment and 14 days after the treatment,the indexes of cardiac function,inflammation and TCM symptom scores were compared between the two groups.Results Before the treatment,there were no significant differences in Left Ventricular End-diastolic Volume(LVEDV),Left ventricular ejection fractions(LVEF)and Left ventricular fractional shortening(LVFS)between the two groups(all P>0.05).After the treatment,the value of LVEDV decreased in both groups,but the values of LVEF and LVFS increased.After the treatment,the value of LVEDV in the observation group was lower than that in the control group,while the values of LVEF and LVFS in the observation group were higher than that in the control group(all P<0.05).Before the treatment,there were no significant differences in tumor necrosis factor-alpha(TNF-alpha),interleukin 6(IL-6),interleukin 8(IL-8),interleukin 10(IL-10),plasma N terminal pro brain natriuretic peptide(NT-proBNP)and cardiac troponin(cTnT)levels between the two groups(P>0.05).After the treatment,the levels of TNF-α,IL-6,IL-8,NT-proBNP and cTnT were all decreased,while the level of IL-10 was increased in both groups.After the treatment,the levels of TNF-α,IL-6,IL-8,NT-proBNP and cTnT in the observation group were lower than those in the control group,while the level of IL-10 was higher than that in the control group(P<0.05).There was no significant difference in the scores of TCM symptoms between the two groups before the treatment(P>0.05).After the treatment,the scores of TCM symptoms in both groups decreased,and the scor

关 键 词：急性失代偿性心力衰竭 利心丸 心功能 炎症因子 

分 类 号：R54[医药卫生—心血管疾病]