西安地区健康儿童血清缺血修饰清蛋白参考区间的建立  

Establishment of Reference Interval for Serum Ischemic Modified Albumin of Healthy Children in Xi’an Area

作　　者：史剑飞 卢北玲 李俏 毛瑞 曹三成[1] 宁远征[1] SHI Jian-fei;LU Bei-ling;LI Qiao;MAO Rui;CAO San-cheng;NING Yuan-zheng(Department of Clinical Laboratory,Xi’an Children’s Hospital,Xi’an 710003,China;Department of Clinical Laboratory,Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710021,China)

机构地区：[1]西安市儿童医院检验科,西安710003 [2]西安市中医医院检验科,西安710021

出　　处：《现代检验医学杂志》2019年第6期118-119,160,共3页Journal of Modern Laboratory Medicine

基　　金：西安市儿童医院院级项目(2018E12)

摘　　要：目的初步建立西安地区健康儿童血清缺血修饰清蛋白(ischemia-modified albumin,IMA)参考区间。方法收集西安市儿童医院保健科2019年7~8月260例健康体检儿童,其中按性别分为男性组140例,女性组120例;按年龄分为≤1岁组41例、1~3岁组56例和≥3岁组163例,采用清蛋白-钴结合法检测血清IMA并进行统计学分析。结果西安地区健康儿童血清IMA呈偏态分布,男性组、女性组、≤1岁组、1~3岁组和≥3岁组的IMA水平分别为70.47±2.64,69.61±3.14,69.71±3.27,70.66±2.77和69.97±2.87 U/ml。不同性别间儿童IMA表达差异有统计学意义(U=6 954,P<0.05),不同年龄组间IMA表达差异无统计学意义(H=1.813,P>0.05)。西安地区健康儿童血清IMA参考区间为:男性0~74.00 U/ml,女性0~75.76 U/ml。结论初步建立西安地区健康儿童血清IMA参考区间,为儿童临床疾病氧化应激损伤的诊断及评估提供参考依据。Objective To establish a reference interval for ischemic-modified albumin(IMA) in healthy children in Xi’an area. Methods A total of 260 healthy children from July to August 2019 who were examined in the Department of Child Health Care in the Xi’an Children’s Hospital were collected.There were 140 males and 120 females by sex.They were divided into ≤ 1 years old group 41 cases,1~3 years old group 56 cases and ≥ 3 years old group 163 cases. Serum IMA levels were measured by albumin-cobalt binding assay and analyzed by statistical methods. Results The serum IMA expression level of healthy children in Xi’an Area was skewed.The IMA levels of the male group,the female group,≤ 1 years old group,1~3 years old group and ≥ 3 years old group were 70.47±2.64,69.61±3.14,69.71±3.27,70.66±2.77 和 69.97±2.87 U/ml,respectively.The difference of serum IMA levels between different genders was statistically significant(U=6 954, P<0.05).There was no significant difference in serum IMA levels between different age groups(H=1.813, P>0.05).The reference range of serum IMA level for healthy children in Xi’an Area was 0~74.00 U/ml, for male, and 0~75.76 U/ml for female. Conclusion The serum IMA reference interval of healthy children in Xi’an Area was preliminarily established,which will provides a reference for the clinical diagnosis of childhood diseases oxidative stress injury and evaluation.

关 键 词：儿童 缺血修饰清蛋白 参考区间 氧化应激 

分 类 号：R446.112[医药卫生—诊断学]