新型[1,2,3]三唑-[4,5-d]嘧啶酮类衍生物的微波法合成  

Microwave Synthesis of Novel [1,2,3] Triazolo [4,5-d] pyrimidin-one Derivatives

作　　者：邓兰青 黄颖 左瑞 易平平 杨红霞 DENG Lan-qing;HUANG Ying;ZUO Rui;YI Ping-ping;YANG Hong-xia(School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学药学院

出　　处：《合成化学》2019年第12期957-961,966,共6页Chinese Journal of Synthetic Chemistry

基　　金：湖南省自然科学基金资助项目(2016JJ4086);湖南省教育厅科研项目(16C1633和17C1204);湖南中医药大学化学工程与技术一流学科建设项目

摘　　要：以卤代烃、邻甲基苯胺、氰基乙酸和乙酰氯为原料,经取代、成环、偶联和关环4步反应,用微波法合成了9个[1,2,3]三唑-[4,5-d]嘧啶酮类衍生物(5a^5i),其中5a^5e,5g和5i为新化合物,其结构经1 H NMR,13 C NMR和HR-MS(ESI)表征。Several[1,2,3]triazolo[4,5-d]pyrimidin-one derivatives(5a^5i,5a^5e,5g and 5i were novel compounds)were synthesized by a four-step microwave-assisted reaction of substitution,ring-formation,coupling and ring-closure reaction using halohydrocarbon,o-toluidine,cyanoacetic acid and acetyl chloride as starting materials.The structures were characterized by 1 H NMR,13 C NMR and HR-MS(ESI).

关 键 词：[1 2 3]三唑-[4 5-d]嘧啶酮 邻甲基苯胺 氰基乙酸 合成 微波 

分 类 号：O626[理学—有机化学]