红花黄色素预防重症破伤风下肢静脉血栓形成的效果  

Effect of safflower yellow on prevention of venous thrombosis in patients with severe tetanus

作　　者：魏金刚 王素星[2] 刘振中[3] 秦浩[4] WEI Jingang;WANG Suxing;LIU Zhenzhong;QIN Hao(Surgical Department,Shijiazhuang Fifth Hospital,Shijiazhuang 050000,China)

机构地区：[1]石家庄市第五医院外科,石家庄050000 [2]河北省人民医院老年病二科,石家庄050000 [3]石家庄市第五医院感染科,石家庄050000 [4]石家庄市第五医院ICU,石家庄050000

出　　处：《实用医学杂志》2019年第22期3527-3530,共4页The Journal of Practical Medicine

基　　金：河北省卫健委科技成果推广项目(编号:20181074)

摘　　要：目的观察红花黄色素预防重症破伤风患者下肢静脉血栓形成的效果及可能机制。方法收集2017年6月至2019年6月我院外科就诊的诊断为重症破伤风患者68例,随机分为对照组34例,给予低分子肝素钙4 100 U皮下注射1次/d;观察组34例,给予红花黄色素氯化钠注射液100 mL静点1次/d,加低分子肝素钙4 100 U皮下注射1次/d。疗程均为14 d。两组分别于治疗前后检测凝血功能、血小板计数、D-二聚体、C反应蛋白、降钙素原、血清TNF-α、IL-18、股静脉血流动力学指标以及下肢静脉血栓的发生情况。结果两组患者经治疗后,凝血功能各指标及股静脉血流动力学指标均有所增加,血小板计数、D-二聚体、C反应蛋白、降钙素原及血清TNF-α、IL-18较治疗前均下降,下肢静脉血栓发生率降低(均P <0.05);红花黄色素组较同期对照组上述指标变化更明显(均P <0.05)。实验过程中两组无不良反应发生。结论红花黄色素可有效改善凝血功能,降低炎症,预防重症破伤风患者下肢静脉血栓形成,效果确切,安全性良好。Objective To observe the effect of safflower yellow on preventing venous thrombosis of lower limbs in patients with severe tetanus and explore its possible mechanism. Methods A total of 68 patients who were hospitalized from June 2017 to June 2019 were diagnosed as severe tetanus in surgical department of our hospital. According to the random number table method,the enrolled patients were randomly divided into two groups. Control group(34 cases)were treated with subcutaneous injection of low molecular weight heparin calcium 4 100 U once a day,and safflower yellow group(43 cases) were treated with subcutaneous injection of low molecular weight heparin calcium 4 100 U once a day plus safflower yellow for 14 days. The coagulation function,platelet count,D-two dimer,C-reactive protein,procalcitonin,serum TNF-α,IL-18,femoral venous hemodynamic parameters and the incidence of venous thrombosis in lower extremities in the two groups were detected before and after treatment. Results After treatment,the value of blood coagulation indexesand femoral venous hemodynamic parameters were increased in both groups,the value of platelet count,D-two dimer,C-reactive protein,procalcitonin,serum TNF-α,IL-18 and the incidence of venous thrombosis in lower extremities were significantly decreased compared with those before treatment(P<0.05);The above indicators in the safflower yellow group experienced a more significant alteration than the control group in the same period(P < 0.05);There was not any occurrence of the side effect in both two groups during the experiment. Conclusions Safflower yellow can effectively prevent venous thrombosis of lower extremities in patients with severe tetanus and have curative positive effect and highlevel of safety. The underlying mechanism may relate to the function of safflower yellow improving coagulation function and reducing inflammation level.

关 键 词：红花黄色素 重症破伤风 下肢静脉血栓 

分 类 号：R47[医药卫生—护理学]