氯吡格雷联合水化预防冠心病介入治疗后不良反应和造影剂肾病的效果  

Efficacy of clopidogrel combined with hydration in prevention of major adverse events and contrast-induced nephropathy after interventional therapy for coronary heart disease

作　　者：李国彪[1] 王高明[1] 孙志刚[1] LI Guobiao;WANG Gaoming;SUN Zhigang(Department of Cardiology,the First People’s Hospital of Fuzhou,Jiangxi Fuzhou 344000,China)

机构地区：[1]江西省抚州市第一人民医院心内科

出　　处：《上海医药》2019年第23期21-22,74,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨氯吡格雷联合水化预防冠心病介入治疗(PCI)后造影剂肾病(CIN)和不良反应的效果。方法:选取110例行PCI手术治疗的患者作为研究对象,按数字随机法分成对照组和观察组各55例,对照组采用阿司匹林肠溶片+水化治疗,观察组采用氯吡格雷+水化治疗,比较两组患者主要心血管事件(MACE)和CIN的发生率,比较给药前后两组患者血小板聚集状况的变化。结果:观察组患者MACE发生率低于对照组,治疗后各时段血小板凝集状态均优于对照组(P<0.05);给药前组间血小板凝集状态和术后1 d组间Scr增幅和Ccr降幅差异均无统计学意义。结论:PCI术后联合使用氯吡格雷+口服水化可有效预防MACE和CIN等的发生率,还可缓解血小板凝集状态。Objective:To investigate the effect of clopidogrel combined with hydration on the prevention of contrastenhanced renal disease(CIN)and adverse reactions after interventional therapy(PCI)for coronary heart disease.Methods:One hundred and ten patients undergoing PCI were enrolled in this study and divided into a control group and an observation group according to a numerical randomization method.The control group was treated with aspirin enteric-coated tablets plus hydration while the observation group with clopidogrel plus hydration.The incidence of main cardiovascular events(MACE)and CIN and the changes of platelet aggregation before and after administration were compared between the two groups.Results:The incidence of MACE was lower and the platelet aggregation status was better in the observation group than the control group(P<0.05).There were no significant differences between the two groups in the platelet aggregation before treatment and the Scr increase and Ccr decrease(P>0.05).Conclusion:The combination of clopidogrel plus oral hydration after PCI can effectively prevent the incidence of MACE and CIN and can also relieve platelet aggregation.

关 键 词：冠心病 氯吡格雷 水化 造影剂肾病 不良反应 

分 类 号：R654.2[医药卫生—外科学] R973.2[医药卫生—临床医学]