卡前列素氨丁三醇联合缩宫素预防425例再次剖宫产产后出血的临床观察  

Clinical observation of carboprost tromethamine combined with oxytocin for the prevention of postpartum hemorrhage in 425 cases of once again cesarean section

作　　者：柳学芳[1] 蒲玉华 王小华[1] LIU Xuefang;PU Yuhua;WANG Xiaohua(Department of Obstetrics,Central Hospital of Qianjiang City,Hubei Qianjiang 433100,China)

机构地区：[1]湖北省潜江市中心医院产科

出　　处：《上海医药》2019年第23期23-24,69,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨卡前列素氨丁三醇联合缩宫素对再次剖宫产术术中预防产后出血的临床效果。方法:选取845例妊娠合并子宫瘢痕再次进行剖宫产孕妇作为研究对象,随机分为观察组(n=425)和对照组(n=420)。观察组例术中采用宫体注射卡前列素氨丁三醇注射液250μg,静脉滴注缩宫素注射液10 U进行预防;对照组采用宫体注射缩宫素10 U,静脉滴注缩宫素10 U方法促子宫收缩。观察两组产后出血发生率、24 h内出血量、药物不良反应。结果:观察组产后出血率显著低于对照组(0.47%vs 1.87%,P<0.05);两组均出现不同程度的不良反应,未行特殊处理,自行缓解。结论:卡前列素氨丁三醇联合缩宫素对预防再次剖宫产产后出血的临床效果明显、安全。Objective:To explore the clinical effect of carboprost tromethamine combined with oxytocin in the prevention of postpartum hemorrhage during the second cesarean section.Methods:Eighty hundreds and forty-five pregnant women with uterine scar were randomly divided into an observation group(n=425)and a control group(n=420).The observation group was treated by intrauterine injection of 250μg carboprost tromethamine and intravenous drip of 10 U oxytocin for prevention.The control group was treated by intrauterine injection of 10 U oxytocin and intravenous drip of 10 U oxytocin for promoting uterine contraction.The incidence of postpartum hemorrhage,the amount of bleeding within 24 hours and adverse drug reactions were observed.Results:The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group(0.47%vs 1.87%,P<0.05).Both groups had different degrees of adverse reactions but they could be self-relieving without special treatment.Conclusion:The clinical effect of carboprost tromethamine combined with oxytocin for the prevention of postpartum hemorrhage after cesarean section is obvious and its safety is good.

关 键 词：再次剖宫产 产后出血 卡前列素氨丁三醇 缩宫素 

分 类 号：R714.461[医药卫生—妇产科学] R984[医药卫生—临床医学]