隔姜灸联合中药离子导入对原发性痛经患者前列腺素代谢物及炎症因子的影响  

Effect of ginger separated moxibustion combined with iontophoresis of traditional Chinese medicine on prostaglandin metabolites and inflammatory factors in patients with primary dysmenorrhea

作　　者：于恬 杜美容 郭洁丽 代凤超 刘秀敏 YU Tian;DU Meirong;GUO Jieli(Department of Traditional Chinese Medicine,Tangshan Maternal and Child Health Hospital,Tangshan,Hebei 063000)

机构地区：[1]河北省唐山市妇幼保健院中医科

出　　处：《河北中医》2019年第10期1545-1549,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(编号:2019238)

摘　　要：目的观察隔姜灸联合中药离子导入对原发性痛经患者前列腺素代谢物及炎症因子的影响。方法将249例原发性痛经患者按照随机数字表法分为3组。对照1组83例予隔姜灸治疗;对照2组83例予中药离子导入治疗;治疗组83例予隔姜灸联合中药离子导入治疗。3组均治疗3个月经周期。比较3组治疗前后[血清前列腺素F2α(PGF2α)、前列腺素E2(PGE2)水平]及炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]水平,并统计3组临床疗效。结果治疗组总有效率93.98%,对照1组总有效率80.72%,对照2组总有效率75.90%,治疗组临床疗效优于对照1组和对照2组(P<0.05)。3组治疗后PGE2水平均升高(P<0.05),PGF2α水平均降低(P<0.05),且治疗组治疗后PGE2水平高于对照1组和对照2组(P<0.05),PGF2α水平低于对照1组和对照2组(P<0.05)。3组治疗后IL-6、hs-CRP、TNF-α水平均降低(P<0.05),且治疗组治疗后IL-6、hs-CRP、TNF-α水平均低于对照1组和对照2组(P<0.05)。结论隔姜灸联合中药离子导入治疗原发性痛经可有效改善患者前列腺素代谢物和炎症指标,疗效优于单纯隔姜灸或单纯中药离子导入。Objective To observe the effect of ginger separated moxibustion combined with iontophoresis of traditional Chinese medicine on prostaglandin metabolites and inflammatory factors in patients with primary dysmenorrhea. Methods 249 patients with primary dysmenorrhea were randomly divided into three groups. 83 cases in control group 1 were treated by ginger separated moxibustion. 83 cases in control group 2 were treated by traditional Chinese medicine iontophoresis. 83 cases in treatment group were treated by ginger separated moxibustion combined with traditional Chinese medicine iontophoresis. The three groups were treated for three menstrual cycles. The serum levels of prostaglandin F2α(PGF2α), prostaglandin E2(PGE2),inflammatory factors[hypersensitive C-reactive protein(hs-CRP), interleukin-6(IL-6) and tumor necrosis factorα(TNF-α)] were compared before and after the treatment in three groups, and the clinical effects of three groups were counted. Results The total effective rate was 93.98% in the treatment group, 80.72% in the control group 1 and 75.90% in the control group 2. The clinical effect of the treatment group was better than that of the control group 1 and the control group 2(P<0.05). After treatment, the level of PGE2 in the three groups was increased(P<0.05), and the level of PGF2αwas decreased(P<0.05). After treatment, the level of PGE2 in the treatment group was higher than that in the control group 1 and control group 2(P<0.05), and the level of PGF2αwas lower than that in the control group 1 and control group 2(P<0.05). After treatment, the levels of IL-6, hs-CRP and TNF-α in the three groups were all decreased(P<0.05). The levels of IL-6, hs-CRP and TNF-α in the treatment group were lower than those in the control group 1 and control group 2(P<0.05).Conclusion Ginger separated moxibustion combined with traditional Chinese medicine iontophoresis can effectively improve the prostaglandin and inflammatory index of patients with primary dysmenorrhea, and the curative effect is better than tha

关 键 词：痛经 隔姜灸 中药离子透入 前列腺素 炎症趋化因子类 

分 类 号：R271.113.05[医药卫生—中医妇科学]