脂联素基因rs1501299和rs2241766多态性与多囊卵巢综合征相关性的Meta分析  

Association of rs1501299 and rs2241766 Single-Nucleotide Polyorphisms in The Adiponectin Gene with The Risk of Polycystic Ovary Syndrome:A Meta-Analysis

作　　者：徐丹 王玉霞[3] 曹伟伟 左萌 张文倩 XU Dan;WANG Yu-xia;CAO Wei-wei;ZUO Meng;ZHANG Wen-qian(Department of Obstetrics,Yueyang Second People's Hospital,Hu'nan Yueyang 414000,China;Department of Urinary Surgery,Yueyang Second People's Hospital,Hu’nan Yueyang 414000,China;Department of Reproductive Medicine,The First Affiliated Hospital,Ji'nan University,Guangzhou 510630,China)

机构地区：[1]岳阳市二人民医院产科,湖南岳阳414000 [2]岳阳市二人民医院泌尿外科,湖南岳阳414000 [3]暨南大学附属第一医院生殖科,广州510630

出　　处：《循证医学》2019年第5期299-308,共10页The Journal of Evidence-Based Medicine

基　　金：2017年广州市科学研究专项资助项目（2060404）

摘　　要：目的系统评价脂联素基因rs1501299和rs2241766多态性与多囊卵巢综合征的相关性。方法计算机检索PubMed、PMC、Web of Science、EMBASE、Cochrane图书馆、中国知网、中国生物医学文献数据库、维普和万方数据库,搜集脂联素基因rs1501299和rs2241766多态性与多囊卵巢综合征相关的病例对照研究,检索时限均从建库至2019年5月。由2名评价者按纳入排除标准独立筛选文献、提取资料,并评价纳入研究的偏倚风险后,采用Stata 12.0软件进行Meta分析。结果共纳入16项脂联素基因rs1501299多态性相关的病例对照研究(包括2349例多囊卵巢综合征患者和3563例健康对照者)。共纳入19项脂联素基因rs2241766多态性相关的病例对照研究(包括2634例多囊卵巢综合征患者和4323例健康对照者)。Meta分析结果显示:敏感性分析剔除Xita研究后表明脂联素基因rs1501299多态性在等位基因、纯合子、显性遗传模式下与多囊卵巢综合征的发病风险有关[T vs.G:比值比=0.82,95%可信区间(0.75,0.90),P=0.000;TT vs.GG:比值比=0.64,95%可信区间(0.51,0.79),P=0.000;TT+TG vs.GG:比值比=0.77,95%可信区间(0.68,0.88),P=0.000],进一步剔除不符合哈迪 温伯格平衡的研究后结果未发生改变,并且剔除Xita及不符合哈迪 温伯格平衡的研究后进行亚组分析提示,脂联素基因rs1501299多态性在不同遗传模式下与亚洲人群多囊卵巢综合征的发病风险有关[T vs.G:比值比=0.80,95%可信区间(0.65,0.99),P=0.04;TT vs.GG:比值比=0.59,95%可信区间(0.37,0.95),P=0.031;TT+TG vs.GG:比值比=0.76,95%可信区间(0.64,0.89),P=0.001],而在高加索人群中无明显相关性[T vs.G:比值比=0.86,95%可信区间(0.70,1.05),P=0.145;TT vs.GG:比值比=0.85,95%可信区间(0.54,1.34),P=0.486;TT+TG vs.GG:比值比=0.78,95%可信区间(0.60,1.02),P=0.067]。在所有纳入的研究中显示脂联素基因rs2241766位点无论在等位基因、纯合子、显性遗传模式下病例组与对照组�Objective To assess the relationship of rs1501299 and rs2241766 single nucleotide polymorphisms(SNPs)in the adiponectin gene(ADIOPQ)with the risk of polycystic ovary syndrome(PCOS).Methods Databases including PubMed,PMC,Web of Science,EMBASE,Cochrane library,CNKI,CBM,VIP and Wanfang were searched from inception to May 2019,and the references of articles were also retrieved to collect case control studies about the correlation of the rs1501299 and rs2241766 polymorphisms of ADIOPQ and PCOS.According to the self designed inclusion and exclusion criteria,two reviewers screened articles,extracted data,and assessed the bias risk of the included studies independently.The Stata 12.0 software was used for meta analysis.Results A total of 16 case control studies involving rs1501299 polymorphisms of ADIOPQ were conducted(including 2349 PCOS cases and 3563 healthy controls).A total of 19 case control studies involving rs2241766 polymorphisms of ADIOPQ were included(including 2634 PCOS cases and 4323 healthy controls).Sensitivity analysis without Xita study revealed obvious correlation between rs1501299 polymorphisms of ADIOPQ with PCOS in alleles,homozygotes and dominant genetic patterns[T vs.G:OR=0.82,95%CI(0.75,0.90),P=0.000;TT vs.GG:OR=0.64,95%CI(0.51,0.79),P=0.000;TT+TG vs.GG:OR=0.77,95%CI(0.68,0.88),P=0.000].The results did not change after further elimination of Hardy Weinberg equilibrium study.The results of subgroup analysis after removal of Xita and non compliance with Hardy Weinberg equilibrium study showed that rs1501299 polymorphisms of ADIOPQ had a correlation with PCOS in Asian population under different genetic pattern[T vs.G:OR=0.80,95%CI(0.65,0.99),P=0.04;TT vs.GG:OR=0.59,95%CI(0.37,0.95),P=0.031;TT+TG vs.GG:OR=0.76,95%CI(0.64,0.89),P=0.001],but not in the Caucasian population[T vs.G:OR=0.86,95%CI(0.70,1.05),P=0.145;TT vs.GG:OR=0.85,95%CI(0.54,1.34),P=0.486;TT+TG vs.GG:OR=0.78,95%CI(0.60,1.02),P=0.067].There were no significant differences in rs2241766 of ADIOPQ between the case group and control group in a

关 键 词：多囊卵巢综合征 脂联素基因 基因多态性 病例对照研究 META分析 

分 类 号：R711.75[医药卫生—妇产科学]