The Mechanisms and Applications of Quorum Sensing(QS) and Quorum Quenching(QQ)  

作　　者：ZHANG Jingjing FENG Tao WANG Jiayi WANG Yan ZHANG Xiao-Hua 

机构地区：[1]College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China [2]Laboratory for Marine Ecology and Environmental Science,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266071,China [3]Institute of Evolution&Marine Biodiversity,Ocean University of China,Qingdao 266003,China

出　　处：《Journal of Ocean University of China》2019年第6期1427-1442,共16页中国海洋大学学报（英文版）

基　　金：supported by the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (CAST) (No. YESS20160009);the National Natural Science Foundation of China (Nos. 31870023, 31571970 and 41506160)

摘　　要：Quorum sensing(QS)is a regulatory system that regulates the behavior of microbial populations by sensing the concentration of signal molecules that are spontaneously produced and released by bacteria.The strategy of blocking the QS system and inhibiting the production of virulence factors is termed as quorum quenching(QQ).This strategy attenuates virulence without killing the pathogens,thereby weakening the selective pressure on pathogens and postponing the evolution of QQ-mediated drug resistance.In recent years,there have been significant theoretical and practical developments in the field of QS and QQ.In particular,with the development and utilization of marine resources,more and more marine microbial species have been found to be regulated by these two mechanisms,further promoting the research progress of QS and QQ.In this review,we described the diversity of QS signals and QS-related regulatory systems,and then introduced mechanisms related to QS interference,with particular emphasis on the description of natural QQ enzymes and chemicals acting as QS inhibitors.Finally,the exploitation of quorum sensing quenchers and the practical application of QQ were introduced,while some QQ strategies were proposed as promising tools in different fields such as medicine,aquaculture,agriculture and biological pollution prevention areas.Quorum sensing(QS) is a regulatory system that regulates the behavior of microbial populations by sensing the concentration of signal molecules that are spontaneously produced and released by bacteria. The strategy of blocking the QS system and inhibiting the production of virulence factors is termed as quorum quenching(QQ). This strategy attenuates virulence without killing the pathogens, thereby weakening the selective pressure on pathogens and postponing the evolution of QQ-mediated drug resistance. In recent years, there have been significant theoretical and practical developments in the field of QS and QQ. In particular, with the development and utilization of marine resources, more and more marine microbial species have been found to be regulated by these two mechanisms, further promoting the research progress of QS and QQ. In this review, we described the diversity of QS signals and QS-related regulatory systems, and then introduced mechanisms related to QS interference, with particular emphasis on the description of natural QQ enzymes and chemicals acting as QS inhibitors. Finally, the exploitation of quorum sensing quenchers and the practical application of QQ were introduced, while some QQ strategies were proposed as promising tools in different fields such as medicine, aquaculture, agriculture and biological pollution prevention areas.

关 键 词：QUORUM sensing QUORUM QUENCHING MARINE MICROORGANISMS antibiotic resistance 

分 类 号：TG1[金属学及工艺—金属学]