基于DNA甲基化推断年龄的研究进展  

Research Progress on Age Estimation Based on DNA Methylation

作　　者：孟航 马开军[1,2] 董利民 李成涛[5] 肖碧 许路易 黄平[5] 谢建辉 MENG Hang;MA Kai-jun;DONG Li-min;LI Cheng-tao;XIAO Bi;XU Lu-yi;HUANG Ping;XIE Jian-hui(Shanghai Key Laboratory of Crime Scene Evidence,Shanghai 200083,China;Institute of Forensic Science,Shanghai Municipal Public Security Bureau,Shanghai 200083,China;Department of Forensic Medicine,Fudan University,Shanghai 200032,China;Minhang Branch of Shanghai Municipal Public Security Bureau,Shanghai 201108,China;Shanghai Key Laboratory of Forensic Medicine,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China)

机构地区：[1]上海市现场物证重点实验室,上海200083 [2]上海市公安局物证鉴定中心,上海200083 [3]复旦大学法医学系,上海200032 [4]上海市公安局闵行分局,上海201108 [5]司法鉴定科学研究院上海市法医学重点实验室上海市司法鉴定专业技术服务平台,上海200063

出　　处：《法医学杂志》2019年第5期537-544,共8页Journal of Forensic Medicine

基　　金：上海市法医学重点实验室开放性课题资助项目(KF1802);上海市现场物证重点实验室开放课题资助项目(2018XCWZK01,2017XCWZK09);上海市公安局科学基金资助项目(2018JBJG)

摘　　要：年龄推断在刑事侦查及司法鉴定领域具有重要的意义,可以为司法部门提供个体的年龄信息,有助于司法工作的开展。近年来,年龄推断方法已从既往的形态学层面拓展至分子生物学层面。随着以DNA甲基化为代表的表观遗传学的迅速发展,以及DNA甲基化检测技术及检测平台不断提升,许多基于DNA甲基化的生物标记及利用各种生物体液(如血液、血痕、唾液、精斑等)的年龄推断方法不断发展。目前,基于DNA甲基化推断年龄的相关研究较多,本文对该方面的研究进行归纳总结,希望能为相关研究和法医学应用提供参考。Age estimation is of great significance in the fields of criminal investigation and forensic identification. It can provide the age information of individuals to judicial departments to facilitate the development of judicial work. In recent years, age estimation methods expanded from the morphological level to the molecular biology level. With the rapid development of epigenetics represented by DNA methylation, and the advancement of DNA methylation detection technology together with the detection platform, many age estimation methods based on DNA methylation biomarkers, or using several biological fluids, such as blood, blood stains, saliva, semen stains, etc. are developed. Currently, researches related to age estimation based on DNA methylation are relatively widely carried out. This paper summarizes the researches on age estimation based on DNA methylation, in order to provide references for related studies and forensic applications.

关 键 词：法医遗传学 DNA甲基化 年龄测定 综述 

分 类 号：DF795.2[医药卫生—法医学]