药物辅助性犯罪案件中替来他明和唑拉西泮及其代谢物的GC-QTOF-MS鉴定  

Identification of Tiletamine, Zolazepam and Their Metabolites in Drug Facilitated Sexual Assault by GC-QTOF-MS

作　　者：何思阳[1] 龚飞君 连茹 盛振海 徐金伦 孙文娟 郑水庆[1] HE Si-yang;GONG Fei-jun;LIAN Ru;SHENG Zhen-hai;XU Jin-lun;SUN Wen-juan;ZHENG Shui-qing(Shanghai Key Laboratory of Criminal Scene Evidence,Institute of Forensic Science of Shanghai Public Security Bureau,Shanghai 200083,China)

机构地区：[1]上海市公安局物证鉴定中心上海市现场物证重点实验室

出　　处：《法医学杂志》2019年第5期581-585,共5页Journal of Forensic Medicine

摘　　要：目的利用气相色谱-四极杆飞行时间质谱法(gas chromatography-quadrupole time of flight mass spectrometry,GC-QTOF-MS)鉴定药物辅助性犯罪案件样品中替来他明和唑拉西泮及其代谢物组分。方法取受害人尿样,经液液萃取后浓缩供GC-QTOF-MS检测。通过精确质量数的测定确认碎片离子的分子式,以鉴定相关物质。结果实际案件尿样中检出替来他明、唑拉西泮、3种替来他明代谢物和2种唑拉西泮代谢物。结论 GC-QTOF-MS提供丰富准确的碎片离子质量数信息,可用于药物辅助性犯罪案件中替来他明和唑拉西泮及其代谢物的定性鉴定。Objective To identify tiletamine, zolazepam and their metabolites in samples from drug facilitated sexual assault by gas chromatography-quadrupole time of flight mass spectrometry(GC-QTOFMS). Methods Urine samples of victims were collected, and detected by GC-QTOF-MS after liquidliquid extraction and concentration. The molecular formula of fragments ions was identified by determination of accurate mass numbers, to detect related substances. Results Tiletamine, zolazepam, three metabolites of tiletamine and two metabolites of zolazepam were identified in urine samples from actual cases. Conclusion GC-QTOF-MS provides abundant and accurate information of fragment ions mass numbers, which can be used for qualitative identification of tiletamine, zolazepam and their metabolites in drug facilitated sexual assault.

关 键 词：法医毒理学 性犯罪 替来他明 唑拉西泮 气相色谱 四极杆飞行时间质谱法 药物辅助 

分 类 号：DF795.1[医药卫生—法医学]