拉贝洛尔联合硝苯地平治疗妊娠高血压患者的疗效及对血清vWF、Apelin水平的影响  

Efficacy of labetalol combined with nifedipine for patients with gestational hypertension and its effect on serum vWF and Apelin levels

作　　者：史玉霞 杨一新 赵敏 SHI Yu-xia;YANG Yi-xin;ZHAO Min(Department of Obstetrics and gynecology,Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University,Wuxi 214002,China)

机构地区：[1]南京医科大学附属无锡妇幼保健院妇产科

出　　处：《广西医学》2019年第22期2829-2832,共4页Guangxi Medical Journal

基　　金：国家自然科学基金(81100437)

摘　　要：目的探讨拉贝洛尔联合硝苯地平治疗妊娠高血压患者的疗效及对患者血清血管性血友病因子(vWF)、血管活性肽Apelin水平的影响。方法将100例妊娠高血压患者随机分为观察组和对照组,每组50例。对照组采用拉贝洛尔治疗,观察组采用拉贝洛尔联合硝苯地平治疗。比较两组患者治疗后1周、治疗后2周的血压及血清vWF、Apelin水平,比较两组患者治疗后2周的治疗效果。结果治疗后1周及治疗后2周,观察组收缩压和舒张压均低于对照组,两组收缩压、舒张压均有随时间变化的趋势,时间与分组有交互作用(均P<0.05);观察组vWF和Apelin水平均低于对照组,两组血清vWF和Apelin水平均有随时间变化的趋势,时间与分组有交互作用(均P<0.05)。观察组患者疗效优于对照组(P<0.05)。结论与单用拉贝洛尔相比,拉贝洛尔与硝苯地平联合应用治疗妊娠高血压患者降压效果更好,并可以改善患者血清vWF、Apelin水平。Objective To explore the efficacy of labetalol combined with nifedipine for the patients with gestational hypertension and its effect on serum von Willebrand factor(vWF) and vasoactive peptide Apelin levels of patients.Methods A hundred patients with gestational hypertension were randomly assigned into observation group or control group,with 50 cases in each group.The control group was treated with labetalol,while the observation group was treated with labetalol combined with nifedipine.The blood pressure,levels of serum vWF and Apelin at 1 and 2 weeks after treatment,as well as the therapeutic effect at 2 weeks after treatment were compared between the two groups.Results At 1 and 2 weeks after treatment,the SBP and DBP of the observation group were lower than those of the control group,the two indicators in both groups exhibited a trend of change over time,and there was a interaction between time and grouping(all P<0.05);the levels of serum vWF and Apelin in the observation group were lower than those in the control group,the serum vWF and Apelin levels exhibited a trend of change over time,and a interaction between time and grouping was found(all P<0.05).The efficacy of patients in the observation group was superior to that in the control group(P<0.05).Conclusion Compare to administration of labetalol alone,the combination of labetalol and nifedipine exerts a better antihypertensive effect on the patients with gestational hypertension,and can improve serum vWF and Apelin levels.

关 键 词：拉贝洛尔 硝苯地平 妊娠高血压 血管性血友病因子 APELIN 血管活性肽 疗效 

分 类 号：R714.2[医药卫生—妇产科学]