99Tcm标记葡萄糖类衍生物肿瘤代谢显像剂的研究进展  

Research Progress of 99Tcm Labeled Glucose Derivatives as Tumor Metabolic Imaging Agents

作　　者：王勤奋[1] 齐秀萍 WANG Qinfen;QI Xiuping(Department of Nuclear Medicine,Sanya Central Hospital(Hainan Province Third People′s Hospital),Sanya 572000,China;Clinical Pharmaceutics Room,Sanya Central Hospital(Hainan Province Third People′s Hospital),Sanya 572000,China)

机构地区：[1]三亚中心医院(海南省第三人民医院)核医学科,海南三亚572000 [2]三亚中心医院(海南省第三人民医院)临床药学室,海南三亚572000

出　　处：《医学综述》2019年第22期4530-4534,4545,共5页Medical Recapitulate

基　　金：海南省卫生计生行业科研项目(19A200139)

摘　　要：肿瘤^18F-2-脱氧氟化葡萄糖正电子发射计算机体层显像(^18F-FDG PET)的临床价值已经被广泛认可,但^18F-FDG PET的缺点是费用昂贵且不是特异的显像。近年来,以核医学最常用核素99 Tc m标记葡萄糖类衍生物的研发和临床应用有了明显进展。^99Tc^m标记葡萄糖类衍生物以类似于^18F-FDG的方式被肿瘤细胞摄取,并参与了细胞核的增殖过程。^99Tc^m标记双半胱氨酸氨基脱氧葡萄糖肿瘤显像已经完成了Ⅱ期临床试验,显示出与^18F-FDG显像相似的诊断效能。其他一些新型^99Tc^m标记葡萄糖类衍生物的临床前生物分布研究显示出优越的显像性能,有望完成显像剂研发的突破,使^99Tc^m标记葡萄糖类衍生物显像成为^18F-FDG肿瘤代谢显像的重要补充。The clinical value of18F-2-deoxy-D-fluoro-glucose positron emission tomograph(18F-FDG PET) tumor imaging has been widely recognized,but its high cost and non-specific imaging constitute its disadvantages. In recent years,the research and clinical application of glucose derivatives labeled with the most commonly used nuclide99Tcmin nuclear medicine have made great progress.99Tcm-labeled glucose derivatives are not only ingested by tumor cells in a manner similar to18F-FDG,but also involved in the process of nuclear proliferation.99Tcm-ethylenedicysteine deoxyglucose has completed phase Ⅱ clinical studies,showing similar diagnostic efficacy to18F-FDG imaging. The preclinical biological distribution studies of other novel99Tcm-labeled glucose derivatives have shown excellent tumor imaging performance and are expected to achieve a breakthrough in the development of imaging agents.99Tcm labeled glucose derivative imaging is becoming an important supplement to18F-FDG tumor metabolism imaging.

关 键 词：葡萄糖类衍生物 锝 放射性示踪剂 肿瘤显像 

分 类 号：R817[医药卫生—影像医学与核医学]