注射用亚胺培南-西司他丁钠致白细胞减少症用药分析  

Analysis of One Case of Leukopenia Induced by Imipenem and Cilastatin Sodium for Injection

作　　者：刘桂良[1] 张芳[1] 朱载瓯 LIU Guiliang;ZHANG Fang;ZHU Zaiou(Department of PharmacyAffilated Stomatological Hospital of Nanjing Medical University,Nanjing 210008;Department of Oral and Maxillofacial Surger,Affilated Stomatological Hospital of Nanjing Medical University,Nanjing 210008)

机构地区：[1]南京医科大学附属口腔医院药剂科,南京210008 [2]南京医科大学附属口腔医院,口腔颌面外科,南京210008

出　　处：《药学与临床研究》2019年第6期471-473,共3页Pharmaceutical and Clinical Research

摘　　要：1例64岁男性患者,因左口咽鳞形细胞癌入院手术治疗。术后术区发生感染,使用亚胺培南-西司他丁治疗前,血常规示白细胞计数(WBC)18.94×10^9/L,中性粒细胞比例(N%)98.84%,中性粒细胞计数(NEUT)17.98×10^9/L,治疗第4天后,血常规示WBC 2.77×10^9/L,N%80.44%,NEUT 2.23×10^9/L。考虑为药源性白细胞减少,停止使用亚胺培南-西司他丁,停用第1天,血常规示WBC 3.53×10^9/L,N%76.24%,NEUT 2.69×10^9/L。停用第3天,血常规示WBC 4.91×10^9/L,N%75.34%,NEUT 3.70×10^9/L,患者生命体征平衡。A 64 years old man diagnosed as left oropharyngeal squamous cell carcinoma got leukopenia and neutropenia after 4 days treatment of imipenem and cilastatin sodium for Surgical Site Infection(SSI).The clinical doctor and pharmacist regarded it as drug-induced leukopenia and suggested to stop the anti-infection treatment of imipenem and cilastatin sodium.The absolute leukocyte counts of the patient returned.

关 键 词：亚胺培南-西司他丁 白细胞减少 

分 类 号：R969.3[医药卫生—药理学]