雷公藤多苷片对难治性肾病综合征患者尿蛋白、炎性因子及免疫功能的影响  

Effects of Tripterygium Wilfordii Polyglycoside Tablets on Urinary Protein, Inflammatory Factors and Immune Function in Patients with Refractory Nephrotic Syndrome

作　　者：焦林娟[1] 陈庆云[1] 石帅[1] 吴霞[1] JIAO Linjuan;CHEN Qingyun;SHI Shuai;WU Xia(Department of Nephrotic Rheumatology,Nanyang Second People's Hospital,Nanyang,Henan,473012,China)

机构地区：[1]南阳市第二人民医院肾病风湿科

出　　处：《临床研究》2020年第1期137-139,共3页Clinical Research

摘　　要：目的探讨雷公藤多苷片对难治性肾病综合征患者尿蛋白、炎性因子及免疫功能的影响。方法选取2014年5月-2015年5月南阳市第二人民医院收治的106例难治性肾病综合征患者为研究对象,采用随机数字表法分为观察组和对照组各53例,两组均给予利尿、降压、低盐低蛋白饮食等综合治疗,对照组加用糖皮质激素,观察组给予雷公藤多苷片联合糖皮质激素治疗。治疗3个月后,比较两组临床疗效、尿蛋白水平、炎性因子、免疫功能指标等指标。结果观察组有效率90.57%明显高于对照组75.47%(χ^2=4.283,P <0.05);尿蛋白定量明显低于对照组,血清白蛋白、总蛋白明显高于对照组(t=5.644,8.612,6.952,P <0.05);血清肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平均明显低于对照组(t=5.649,5.143,12.885,P <0.05);T淋巴细胞亚群平CD3^+、CD4^+及CD4/CD8均明显高于对照组(t=4.122,6.002,4.054,P <0.05)。结论雷公藤多苷片有助于提高难治性肾病综合征患者临床疗效,可能与控制蛋白尿表达、缓解炎症反应、改善免疫功能等有关。Objective To investigate the effect of tripterygium wilfordii polyglycoside tablets on urinary protein, inflammatory factors and immune function in patients with refractory nephrotic syndrome. Methods 106 patients with refractory nephrotic syndrome admitted to Nanyang Second People’s Hospital from May 2014 to May 2015 were selected as the research object,and divided into observation group and control group(53 cases in each group). Both groups were treated with a comprehensive treatment, such as diuresis, step-down, the low-salt, low-protein diet, the control group used glucocorticoid, while the observation group was given tripterygium wilfordii glycosides tablets with glucocorticoid therapy. Terms of clinical efficacy, urine protein level, inflammatory factors, immune function and other indicators between the two groups were compared after 3 months of treatment. Results The effective rate in the observation group(90.57%) was higher than that in the control group(75.47%)(χ^2=4.283, P < 0.05). The quantitative value of urine protein was significantly lower than that of the control group, and serum albumin and total protein were significantly higher than that of the control group(t=5.644, 8.612, 6.952, P < 0.05). Serum levels of tumor necrosis factor-α(TNF-α), high sensitivity c-reactive protein(hs-CRP) and interleukin-6(IL-6) were significantly lower than those in the control group(t=5.649, 5.143, 12.885, P < 0.05). The T lymphocyte subsets CD3^+, CD4^+ and CD4/CD8 were significantly higher than the control group(t =4.122, 6.002, 4.054, P < 0.05). Conclusion Tripterygium wilfordii polyglycoside tablets can improve the clinical efficacy of refractory nephrotic syndrome patients, which may be related to the control of proteinuria expression, the alleviation of inflammatory response, and the improvement of immune function.

关 键 词：难治性肾病综合征 雷公藤多苷片 蛋白尿 炎性因子 免疫功能 

分 类 号：R256.5[医药卫生—中医内科学]