C3H10T1/2细胞黏着斑与微丝及细胞面积的相关性研究  

Study on the Correlation among Focal Adhesion and Microfilaments and Cell Areas of C3H10T1/2

作　　者：李司婧 董红丽 Li Sijing;Dong Hongli(College of Engineering,Dali University,Dali,Yunnan 671003,China)

机构地区：[1]大理大学工程学院

出　　处：《大理大学学报》2019年第12期75-78,F0004,共5页Journal of Dali University

基　　金：大理大学青年教师科研基金资助项目（KYQN201434）

摘　　要：黏着斑是将细胞外基质与细胞骨架联系起来的多蛋白聚集体,可形成细胞迁移的伪足。微丝对细胞贴附、铺展、运动、内吞、细胞分裂等许多细胞功能具有重要作用。对间充质干细胞(C3H10T1/2)骨架系统进行研究,通过采用ZEN、ImageJ以及SPSS等软件分析黏着斑、微丝以及细胞面积之间的关系。实验结果显示,微丝总长度与黏着斑数量、黏着斑面积与黏着斑数量、细胞面积与黏着斑数量均存在显著的相关关系。Focal Adhesion is a multi protein aggregate linked by extracellular matrix and cytoskeleton, forming the pseudopodium for cell migrations. Microfilaments play an important role in cell adhesion, spreading, movement, endocytosis, cell division and many other cell functions. This paper studies the cytoskeleton system of C3 H10 T1/2 cells through analyzing the correlation between Focal Adhesion and microfilaments and cell areas based on ZEN, ImageJ and SPSS. The results show the significant correlation between the number of Focal Adhesion and total length of microfilaments, of the area of the plaque and the number of Focal Adhesion, and of the cell area and the number of focal Adhesion.

关 键 词：间充质干细胞 细胞骨架 微丝 黏着斑 

分 类 号：Q245[生物学—细胞生物学]