艾普拉唑与奥美拉唑治疗幽门螺杆菌相关十二指肠溃疡的疗效比较  

Comparison of Efficacy Between Ilaprazole and Omeprazole in Treatment of Helicobacter Pylori-Associated Duodenal Ulcer

作　　者：石振东 赵凤娥 陈莫耶[2] SHI Zhendong;ZHAO Feng’e;CHEN Moye(Dept.of General Internal Medicine,Tiefa Coal General Hospital of Liaoning Health Industry Group,Liaoning Tieling 112700,China;Dept.of Gastroenterology,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110000,China)

机构地区：[1]辽宁健康产业集团铁煤总医院综合内科,辽宁铁岭112700 [2]中国医科大学附属第一医院消化内科,辽宁沈阳110000

出　　处：《中国医院用药评价与分析》2019年第12期1485-1487,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：辽宁省自然科学基金指导计划项目（No.20180550049）

摘　　要：目的:比较艾普拉唑与奥美拉唑治疗幽门螺杆菌(Helicobacter pylori,Hp)相关十二指肠溃疡(duodenal ulcer,DU)的临床疗效.方法:选取2015年1月至2018年8月中国医科大学附属第一医院消化内科收治的Hp相关DU患者206例,按照随机数字表法分为观察组(103例)和对照组(103例).两组患者同时应用阿莫西林、克拉霉素和胶体果胶铋,观察组患者加用艾普拉唑肠溶片,对照组患者加用奥美拉唑肠溶胶囊.比较两组患者的临床疗效和不良反应发生情况的差异.结果:治疗后,两组患者的症状评分均较治疗前明显降低,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);观察组患者的症状缓解时间明显短于对照组,Hp转阴率、溃疡愈合率及溃疡复发率明显优于对照组,差异均有统计学意义(P<0.05).观察组患者的不良反应发生率为8.74%(9/103),明显低于对照组的16.67%(18/103),差异有统计学意义(P<0.05).结论:艾普拉唑四联疗法和奥美拉唑四联疗法均可有效治疗Hp相关DU,而艾普拉唑四联疗法在缓解症状、愈合溃疡、根除Hp及预防溃疡复发方面效果更显著,且安全性更佳.OBJECTIVE:To compare the clinical efficacy between ilaprazole and omeprazole in treatment of Helicobacter pylori(Hp)-associated duodenal ulcer(DU).METHODS:206 patients with Hp-associated DU admitted into gastroenterology department of the First Affiliated Hospital of China Medical University from Jan.2015 to Aug.2018 were selected and divided into observation group and control group via random number table,with 103 cases in each group.Both groups were treated with amoxicillin,clarithromycin and colloidal bismuth pectin,on that basis,the observation group was given ilaprazole enteric-coated tablets and the control group was given omeprazole enteric-coated tablets.Differences in clinical efficacy and incidences of adverse drug reactions between two groups were compared.RESULTS:After treatment,the symptom scores of both groups had been significantly decreased,and that of the observation group was significantly lower than the control group,with statistically significant differences(P<0.05);the remission time of observation group was significantly shorter than that of the control group,the negative conversion ratio of Hp,healing rate and recurrence rate of ulcer of observation group were significantly better than those of the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions of observation group was 8.74%(9/103),which was significantly lower than that of the control group(16.67%,18/103),with statistically significant difference(P<0.05).CONCLUSIONS:Both the four-drug combination therapy of ilaprazole and omeprazole can effectively treat Hp-associated DU,while the four-drug combination therapy of ilaprazole has better effects in relieving symptoms,healing ulcer,eradicating Hp and preventing recurrence,with higher safety.

关 键 词：质子泵抑制剂 消化性溃疡 幽门螺杆菌 疗效 安全性 

分 类 号：R975[医药卫生—药品]