5-HT3R与CB1R对经前烦躁障碍的不同作用机制  

Different Mechanisms of 5-HT3R and CB1R to PMDD

作　　者：杨焕新[1] 高明周[2] 张浩[2] 牟翔宇 蔡亚伟 YANG Huanxin;GAO Mingzhou;ZHANG Hao;MOU Xiangyu;CAI Yawei(Qilu University of Technology,Jinan 250355,China;Shandong University of Traditional Chinese Medicine)

机构地区：[1]齐鲁工业大学,山东济南250355 [2]山东中医药大学

出　　处：《西部中医药》2019年第11期136-138,共3页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金项目(编号81703941);山东省自然科学基金(编号ZR2017PH077)

摘　　要：探讨经前烦躁障碍[premenstrual dysphoric disorder,PMDD,重度经前期综合征(premenstrual syndrome,PMS)]肝气逆及肝气郁两证中5-羟色胺3受体(5-HT3R)与大麻黄受体1(CB1R)的含量,探索两证异常具有的同中存异特征,指出肝疏泄失常所致肝气逆证、肝气郁证为重度经前期综合征(PMS)主证,已知5-HT3R与CB1R共表达于情绪调控脑区γ-氨基丁酸(GABA)神经元,因此深入探索5-HT3R与CB1R对PMDD作用机制有可能揭示“肝主疏泄调畅情志”的本质。The contents of 5-HT3R and CB1R were studied to find out the abnormality of two patterns in the patients suffering premenstrual dysphoric disorder(PMDD)and severe premenstrual syndrome(PMS)of liver Qi reversing pattern and liver Qi depression pattern,it was pointed out that liver Qi reversing pattern and liver Qi depression pattern caused by abnormal liver catharsis have become the main pattern of severe PMS,both 5-HT3R and CB1R were expressed in the common region mood-control brain region GABA neuron,in-depth exploration into the mechanism of 5-HT3R and CB1R on PMDD might reveal the nature of"liver governing catharsis and regulating the moods".

关 键 词：经前烦躁障碍 经前期综合征 5-HT3R CB1R 肝气逆证 肝气郁证 

分 类 号：R271[医药卫生—中医妇科学]