一种绿色安全的头孢噻吩酸合成工艺  

Study on the Green Synthesis of Cephalotin Acid

作　　者：虞正烨 叶思思 黄文海[2] YU Zheng—ye;YE Si-si;HUANG Wen—hai(Zhejiang Dongbang Pharmaceutial Co.,Ltd.,Taizhou,Zhejiang 317016,China;Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province,Institute of Materia Medica,Zhejiang Academy of Medical Sciences,Hangzhou,Zhejiang 310013,China)

机构地区：[1]浙江东邦药业有限公司,浙江台州317016 [2]浙江省医学科学院药物研究所,浙江省神经精神疾病药物研究重点实验室,浙江杭州310013

出　　处：《浙江化工》2019年第12期4-5,共2页Zhejiang Chemical Industry

基　　金：浙江省神经精神疾病药物研究重点实验室资助项目(2019E10021)

摘　　要：头孢噻吩酸是合成头孢噻吩钠和头孢西丁钠抗菌药物的重要中间体。现有生产工艺使用了化学性质不稳定的噻吩乙酰氯作为原料,具有强烈的刺激性气味,且需要低温反应,能耗、三废等相对较大。目的:在目前的环保和安全生产的大趋势下,寻找替代噻吩乙酰氯的合成工艺。方法:采用噻吩乙酸替代噻吩乙酰氯,开发了一条新工艺。结果:新工艺可以高收率地获得产品,摩尔收率为94.4%。结论:本文开发的路线是一条环境友好,条件温和,利于工业化生产的绿色合成工艺。Cephalotin acid is an important intermediate for the synthesis of antibacterial drugs of cephalotin sodium and cefoxitin sodium.The existing production process uses chemically unstable thiophene acetyl chloride as a raw material,has a strong irritating odor,and requires a low-temperature reaction,and has relatively large energy consumption and three wastes.Objective:In the current general trend of environmental protection and safe production,find a synthetic process to replace thiophene acetyl chloride.Method:A new process was developed using thiopheneacetic acid instead of thiopheneacetyl chloride.Results:The new process can obtain products with high yield,and the molar yield is 94.4%.Conclusion:The route developed in this article is a green synthesis process that is environmentally friendly,mild,and conducive to industrial production.

关 键 词：头孢噻吩酸 绿色合成 安全生产 

分 类 号：TQ2[化学工程—有机化工]