甾体类药物的微生物转化制备技术新进展  

Progress in Microbial Transformation Technology for Preparation of Steroid Drugs

作　　者：吴天飞 潘建洪 方从申 陈凯 WU Tian-fei;PAN Jian-hong;FANG Cong-shen;CHEN Kai(Taizhou Xianju Pharmaceutical Co.,Ltd.,Taizhou,Zhejiang 317016,China)

机构地区：[1]台州仙琚药业有限公司

出　　处：《浙江化工》2019年第12期25-28,共4页Zhejiang Chemical Industry

摘　　要：利用微生物转化技术制备甾体类药物的反应过程中,甾体类化合物底物的水难溶性带来的传质问题成为制约反应产率的主要因素之一,反应介质体系的选择与生物催化效率密切相关。本文以微生物催化制备甾体类药物反应为对象,就水相体系、双水相体系、双液相体系,以及含离子液体介质体系和低共熔溶剂体系等不同介质体系中的微生物转化甾体类化合物的制备技术研究及新进展进行了论述与展望。In the process of preparing steroids by microbial transformation technology,the mass transfer problem caused by water insolubility of steroids becomes one of the main factors which restricting the reaction yield.Thus,the choice of reaction medium system is closely related to the biocatalysis efficiency.In this paper,the preparation of steroid reactions by microbial catalysis was reviewed and prospected in the study of microbial transformation techniques in different media systems,including aqueous phase transformation,organic-aqueous two phase transformation,ionic liquid or deep eutectic solvent-containing systems.

关 键 词：微生物催化 反应介质 甾体类药物 

分 类 号：TS2[轻工技术与工程—食品科学与工程]