HPV单一感染与多重感染对宫颈病变影响的临床分析  

Clinical analysis of the effects of HPV single infection and multiple infections on cervical lesions

作　　者：黄春优[1] 王碧霞[1] 李华梅 HUANG Chunyou;WANG Bixia;LI Huamei(Department of Obstetrics and Gynecology,Dongguan Humen Hospital,Dongguan 523900,China)

机构地区：[1]广东省东莞市虎门医院妇产科

出　　处：《中国医药科学》2019年第23期136-138,共3页China Medicine And Pharmacy

摘　　要：目的探讨高危型人乳头瘤病毒(HPV)单一感染与多重感染对宫颈病变造成影响的差异。方法选取2015年1月~2018年12月在我院门诊就诊的不典型鳞状上皮细胞及其以上级别患者1127例,行HPV检测及阴道镜宫颈组织病理学诊断。根据HPV的分型结果将679例HPV阳性患者分为单一高危型HPV感染组521例、多重高危型HPV感染组89例、高低危型混合HPV感染组69例。比较各亚型高危HPV感染情况及三组患者宫颈组织病理学结果。结果单一高危型HPV感染组HPV分型分别为16型(12.22%)、18型(6.48%)、31型(4.41%)、33型(3.38%)、35型(4.86%)、39型(4.27%)、45型(3.97%)、51型(5.89%)、52型(5.74%)、53型(5.15%)、56型(7.36%)、58型(3.24%)、59型(3.97%)、66型(3.82%)、68型(1.91%);多重高危型HPV感染组为HPV16型和其他(8.24%)、除外HPV16型其他多重高危HPV(4.86%);高低危型混合HPV感染组为HPV16型和低危(5.00%)、除外HPV16型其他高危和低危型HPV(5.15%)。单一高危型HPV感染组与多重高危型HPV感染组患者宫颈组织病理学结果差异有统计学意义(P <0.05);单一高危型HPV感染组与高低危型混合HPV感染组患者宫颈组织病理学结果差异无统计学意义(P> 0.05);多重高危型HPV感染组与高低危型混合HPV感染组患者宫颈组织病理学结果差异有统计学意义(P <0.05)。结论与单一高危HPV感染相比,多重高危型HPV感染可以促进宫颈病变的发展。Objective To explore the difference in effects between the single infection of high-risk human papillomavirus(HPV)and multiple infections on cervical lesions. Methods From January 2015 to December 2018,1127 patients with atypical squamous epithelial cells or above who were admitted to the outpatient department of our hospital were selected for HPV detection and cervical histopathological diagnosis by colposcope.According to the HPV classification results,679 HPV-positive patients were divided into 521 patients with single high-risk HPV infection,89 patients with multiple high-risk HPV infection and 69 patients with high-low risk mixed HPV infection.The high-risk HPV infection of each subtype was compared and the pathological findings of cervical tissue in three groups were compared. Results The HPV classification of single high-risk HPV infection group was type 16(12.22%),type 18(6.48%),type 31(4.41%),type 33(3.38%),type 35(4.86%),type 39(4.27%),type 45(3.97%),type 51(5.89%),type 52(5.74%),type 53(5.15%),type 56(7.36%),type 58(3.24%),type 59(3.97%),type 66(3.82%)and type 68(1.91%).The HPV classification of multiple high-risk HPV infection group was HPV16 and others(8.24%)and the other multiple high-risk HPV without HPV16(4.86%).The HPV classification of high-low risk mixed HPV infection group was HPV16 and low risk(5.00%)and other high-risk and low-risk HPV without HPV16(5.15%).There were statistically significant differences in cervical histopathological results between the single high-risk HPV infection group and the multiple high-risk HPV infection group(P < 0.05).There was no statistically significant difference in cervical histopathological results between the single high-risk HPV infection group and the high and low risk mixed HPV infection group(P > 0.05).There were statistically significant differences in cervical histopathological results between the multiple high-risk HPV infection group and the high and low risk mixed HPV infection group(P <0.05). Conclusion Compared with single high-risk HPV infection

关 键 词：HPV 单一感染 多重感染 宫颈病变 

分 类 号：R711.74[医药卫生—妇产科学]