护理干预对美罗华联合CHOP治疗B细胞性非霍奇金淋巴瘤后临床疗效及不良反应的影响研究  

Research on effects of nursing intervention on clinical effects and adverse reactions of rituximab combined with CHOP in treatment of B-cell non-hodgkin lymphoma

作　　者：赵立丽 刘丹 窦勤玲 闫文婷 ZHAO Lili;LIU Dan;DOU Qinling;YAN Wenting(Department of Hematology,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang,Mudanjiang 157000,China)

机构地区：[1]牡丹江医学院附属红旗医院血液科

出　　处：《中国医药科学》2019年第23期155-157,共3页China Medicine And Pharmacy

摘　　要：目的研究护理干预对美罗华(Rituximab)联合CHOP(R-CHOP)治疗B细胞性非霍奇金淋巴瘤临床疗效及不良反应的影响。方法选取2012年1月~2014年1月我院诊断为B细胞性非霍奇金淋巴瘤患者41例,随机分为对照组20例和观察组21例。对照组给予常规护理,观察组在常规护理的基础上给予护理干预措施,比较4个疗程后两组患者的疗效、不良反应发生率、护理满意度和生活质量评分。结果观察组患者病情缓解率高于对照组,但差异无统计学意义(P> 0.05),观察组不良反应发生率低于对照组,其中恶心呕吐及脱发发生率差异有统计学意义(P <0.05)。观察组护理满意度和生活质量评分高于对照组,差异有统计学意义(P <0.05)。结论护理干预措施有助于降低部分不良反应的发生,提高护理满意度和患者的生存质量。Objective To explore the effects of nursing intervention on clinical effects and adverse reactions of rituximab combined with CHOP(R-CHOP) in treating B-cell non-Hodgkin lymphoma. Methods 41 patients who were diagnosed as B-cell non-Hodgkin lymphoma in our hospital from January 2012 to January 2014 were selected. They were randomly divided into the control group(20 cases) and the observation group(21 cases). The control group was given routine nursing while the observation group was given nursing intervention based on routine nursing. The curative effects, incidence of adverse reaction, nursing satisfaction and quality of life score were compared between those two groups after four treatment courses. Results The remission rate of observation group was higher than that of control group, however, the difference was not statistically significant(P > 0.05). The incidence of adverse reaction of observation group was lower than that of control group, and the difference in the incidence of nausea, vomiting and hair loss was statistically significant(P < 0.05). The nursing satisfaction and quality of life score of observation group was significantly higher than that of the control group. The difference was statistically significant(P < 0.05). Conclusion Nursing intervention measures could reduce the occurrence of adverse reaction and improve nursing satisfaction and quality of life of patients.

关 键 词：美罗华 B细胞性非霍奇金淋巴瘤 护理干预措施 满意度 生存质量 疗效 

分 类 号：R473.73[医药卫生—护理学]