急性主动脉夹层发生机制的病理生理学研究进展  

Progress in pathophysiology of acute aortic dissection

作　　者：李根 刘达兴 LI Gen;LIU Da-xing(Department of Cardiovascular Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,CHINA)

机构地区：[1]遵义医科大学附属医院心血管外科

出　　处：《海南医学》2019年第24期3247-3249,共3页Hainan Medical Journal

基　　金：国家自然科学基金(编号：81260056)

摘　　要：急性主动脉夹层是一种病情危重、发展迅速、病死率高的以胸背部剧烈疼痛为主要表现的主动脉疾病。近年来,急性主动脉夹层的发生率增多,被认为有可能是与医疗卫生条件改善与健康意识加强有关系。急性主动脉夹层是最严重的急性大动脉综合征之一,严重影响患者生命安全和生存质量,其发生发展的原因多、机制复杂,目前仍未被心脏大血管外科研究者完全理清阐明。所以,关于其发生发展的研究尤为临床所迫切需要。本文综述近年来急性主动脉夹层病理生理学机制的研究进展与热点,以期提高心脏大血管外科工作者对主动脉夹层的认识,提高诊疗水平。Acute aortic dissection is a kind of aortic disease characterized by severe pain in the chest and back,which is critically ill,rapid development,and high mortality.In recent years,the incidence of acute aortic dissection has increased,and it is thought that it may be related to the improvement of medical and health conditions and the strengthening of health awareness.Acute aortic dissection is one of the most serious acute aortic syndromes,which seriously affects patients'life safety and quality of life.It has many causes and mechanisms,and it has not been completely clarified by the researchers of cardiac major vascular surgery.Therefore,research on its occurrence and development is particularly urgent for clinical needs.This article reviews the research progress and hotspots of the pathophysiological mechanism of acute aortic dissection in recent years,in order to improve the understanding of aortic dissection by cardiac vascular surgeons and improve the level of diagnosis and treatment.

关 键 词：主动脉夹层 动脉瘤 病理生理学 机制 动物模型 

分 类 号：R654.2[医药卫生—外科学]