非活动性HBsAg携带者合并遗传性球形红细胞增多症1例并文献复习  

A case of nonactive HBsAg carrier with hereditary spherocytosis and literature review

作　　者：刘丽改 丁蕊 王琦 王艳斌 张婷 范颖 曹颖 王京京 程澄 谢雯 LIU Li-gai;DING Rui;WANG Qi;WANG Yan-bin;ZHANG Ting;FAN Ying;CAO Ying;WANG Jing-jing;CHENG Cheng;XIE Wen(Center of Hepatology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院肝病一科

出　　处：《中国肝脏病杂志（电子版）》2019年第4期94-96,共3页Chinese Journal of Liver Diseases：Electronic Version

基　　金：北京市重大科技专项（D171100003117005）

摘　　要：慢性乙型肝炎免疫清除或活动引起的肝细胞或胆管细胞损伤表现为胆红素升高时,以直接胆红素升高为主。遗传性球形红细胞增多症(hereditary spherocytosis,HS)临床表现差异较大,需结合实验室检查、骨髓穿刺和基因检测等辅助诊断。慢性乙型肝炎患者出现以间接胆红素升高为主的肝功能损伤时,需警惕溶血、Gilbert综合征及Crigler-Najjar综合征等,目前尚无资料显示HS的发病与慢性乙型肝炎相关。本文现报道1例非活动性HBsAg携带者合并HS并进行文献复习。The injury of hepatocytes or bile duct cells caused by chronic hepatitis B can be manifested as the elevation of bilirubin, mainly the elevation of direct bilirubin. The clinical manifestations of hereditary spherocytosis(HS). Laboratory examination, bone marrow puncture and gene detection are needed to assist the diagnosis. Patients with chronic hepatitis B should be vigilant against hemolysis, Gilbert syndrome and Crigler-Najjar syndrome in the event of liver injury with elevated indirect bilirubin. At present, there is no evidence shows that the incidence of HS is associated with chronic hepatitis B. A case of non-active HBsAg carrier with HS was reported and reviewed in this paper.

关 键 词：肝炎 乙型 慢性 溶血 遗传性球形红细胞增多症 

分 类 号：R51[医药卫生—内科学]