雷公藤的抗炎抗免疫作用研究进展  

Research Progress in Anti-inflammatory and Anti-immune Effects of Tripterygium Wilfordii

作　　者：周俊 徐艳 臧银善 ZHOU Jun;XU Yan;ZANG Yinshan(Department of Rheumatology and Immunology,Suqian First People's Hospital,Suqian 223800,China)

机构地区：[1]宿迁市第一人民医院风湿免疫科

出　　处：《医学综述》2019年第24期4855-4859,共5页Medical Recapitulate

基　　金：宿迁市科技计划项目(S201418)

摘　　要：雷公藤是目前临床使用较多的中药免疫抑制剂,其具有抗炎、抗免疫、抗增殖、促凋亡等作用,在多种自身免疫性和炎症性疾病中有广泛应用。雷公藤及其提取物发挥抗炎抗免疫作用的过程十分复杂,主要涉及免疫细胞(T淋巴细胞、B淋巴细胞、树突状细胞、单核细胞、巨噬细胞等)、炎症介质(肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1β等)、酶类等,具体机制有待进一步研究。因此,探索雷公藤的抗炎抗免疫作用机制具有重要意义。相信随着研究的不断深入,未来雷公藤的抗炎抗免疫作用将会得到更深的认识,其将用于更多疾病的治疗。Tripterygium wilfordii is an immunosuppressant of traditional Chinese medicine which is widely used in clinic.It has anti-inflammatory,anti-immune,anti-proliferation,pro-apoptosis effects,and it is widely used in a variety of autoimmune and inflammatory diseases.Tripterygium wilfordii and its extract play an anti-inflammatory and anti-immunity role in a very complex process,mainly involving immune cells(T lymphocyte,B lymphocyte,dendritic cells,monocytes,macrophages etc.),inflammatory mediators(tumor necrosis factor-α,interleukin-6,interleukin-1βetc.)and enzymes.although the specific mechanisms need to be further studied.Therefore,it is of great significance to explore the anti-inflammatory and anti-immune mechanism of tripterygium wilfordii.It is believed that with the deepening of research,the anti-inflammatory and anti-immune effects of tripterygium wilfordii will be better understood and applied to the treatment of more diseases in the future.

关 键 词：雷公藤 抗炎 抗免疫 

分 类 号：R285[医药卫生—中药学]