人卵母细胞冷冻研究进展  

Research Progress in Human Oocyte Cryopreservation

作　　者：杨金姬 李红义 YANG Jinji;LI Hongyi(Department of Reproductive Medicine,Characteristic Medical Center of Chinese People's Armed Police Force,Tianjin 300162,China)

机构地区：[1]武装警察部队特色医学中心军人生殖医学科

出　　处：《医学综述》2019年第24期4940-4944,共5页Medical Recapitulate

摘　　要：玻璃化冷冻技术是目前最有效的卵母细胞冷冻方法,已广泛应用于女性生育力保存。不同医学中心卵母细胞冷冻成功率的差异较大,女性年龄、卵母细胞成熟度及其冷冻方法、冷冻载体和冷冻保存时间是影响卵母细胞冷冻临床结局的主要因素。由于成熟卵母细胞具有体积大、表面积体积比小、含水量高、细胞内含物特殊和存在减数分裂纺锤体的特点,其在冷冻复苏过程中极易发生冷冻损伤。卵母细胞冷冻保存与产科和围生期并发症的发生率升高无关,但仍需密切关注其子代安全。Vitrification is the most effective method of oocyte cryopreservation and has been widely used in female fertility preservation.The success rate of oocyte cryopreservation varies greatly among different medical centers.Women's age,maturity of oocyte and cryopreservation method,cryopreservation carrier and cryopreservation time are the main factors affecting the clinical outcome of oocyte cryopreservation.Due to the characteristics of large volume,small surface area ratio,high water content,special intracellular contents and the presence of meiotic spindles,mature oocytes are prone to freeze injury during cryopreservation.Oocyte cryopreservation is not associated with increased incidence of obstetric and perinatal complications,but the safety of the offspring still needs close attention.

关 键 词：卵母细胞冷冻 玻璃化冷冻 生育力保存 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]