Radial artery access site complications during cardiac procedures,clinical implications and potential solutions: The role of nitric oxide  

作　　者：Emma M Coghill Timothy Johnson Russell E Morris Ian L Megson Stephen J Leslie 

机构地区：[1]Free Radical Research Facility,Division of Biomedical Sciences,University of the Highlands and Islands,Inverness IV23JH,United Kingdom [2]Johnson Matthey Technology Centre,Blount’s Court,Sonning Common,Reading RG49NH,United Kingdom [3]School of Chemistry,University of St.Andrews,St Andrews KY169ST,United Kingdom [4]Department of Cardiology,NHS Highland,Inverness IV23UJ,United Kingdom

出　　处：《World Journal of Cardiology》2020年第1期26-34,共9页世界心脏病学杂志（英文版）（电子版）

基　　金：Supported by the European Social Fund and Scottish Funding Council as part of Developing Scotland’s Workforce in the Scotland 2014-2020 European Structural and Investment Fund Programme

摘　　要：Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery,as this is considered to be safer than the femoral approach.However,despite improvements in technology and techniques,complications can occur.The most common complication,arterial spasm,can cause intense pain and,in some cases,procedural failure.The incidence of spasm is dependent on several variables,including operator experience,artery size,and equipment used.An antispasmolytic cocktail can be applied to reduce spasm,which usually includes an exogenous nitric oxide(NO)donor(glyceryl trinitrate).NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention.However,systemic administration can result in unwanted side-effects,such as hypotension.A method that adopts local delivery of NO might be advantageous.This review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm,and highlight the potential of NO-loaded nanoporous materials for use in this setting.Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery, as this is considered to be safer than the femoral approach. However, despite improvements in technology and techniques, complications can occur. The most common complication, arterial spasm, can cause intense pain and, in some cases,procedural failure. The incidence of spasm is dependent on several variables,including operator experience, artery size, and equipment used. An antispasmolytic cocktail can be applied to reduce spasm, which usually includes an exogenous nitric oxide(NO) donor(glyceryl trinitrate). NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention.However, systemic administration can result in unwanted side-effects, such as hypotension. A method that adopts local delivery of NO might be advantageous.This review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm, and highlight the potential of NO-loaded nanoporous materials for use in this setting.

关 键 词：Radial artery CANNULATION SPASM Nitric oxide VASODILATION Nanoporous material 

分 类 号：O17[理学—数学]